Forest Ray PhD,  —

Loss of muscle mass, also known as sarcopenia, is common among people with Cushing’s syndrome in long-term remission, and is associated with a poorer quality of life, a study reported. Its researchers also found the Sarcopenia Index, a blood test that can be used to estimate a patient’s muscle…

A young woman with psychosis stemming from Cushing’s disease made a complete recovery through a combination of brain surgery and Metopirone (metyrapone) treatment, according to a case report. The researchers noted that Cushing’s disease is challenging to diagnose and often occurs alongside neuropsychiatric symptoms. Catching and treating…

Some 25% of Cushing’s disease patients — or 1 in every 4 — will develop Nelson’s syndrome (NS) after surgery to remove both adrenal glands, while around 1 in every 5 will need pituitary-specific treatment, a study found. Lifelong follow-up is also needed for patients who undergo double adrenal gland…

A woman with a rare case of Cushing’s disease, in which rising cortisol triggered the production of yet more cortisol, may represent a new subtype of the disorder. She was the focus of the recent case report “Tumor shrinkage by metyrapone in Cushing’s disease exhibiting glucocorticoid-induced…

Cortisol fluctuations in a woman with Cushing’s disease were controlled successfully with Signifor (pasireotide LAR), possibly for the first time, according to a recent case report. The report, “Resolution of cyclicity after pasireotide LAR in a patient with Cushing’s disease,” was published in the journal…

Recorlev (levoketoconazole), Strongbridge Biopharma’s oral investigational therapy for endogenous Cushing’s syndrome, led to sustained improvements in cortisol and in blood sugar control among patients with both Cushing’s and diabetes, a subgroup analysis of Phase 3 SONICS trial data showed. “Diabetes mellitus [type 1 diabetes] is among the…

Although mortality rates associated with endogenous Cushing’s syndrome have dropped in recent years, the disease is still linked to a threefold increase in the risk of death, mainly from cardiovascular issues and infections, a recent analysis of past research has found. “Our results found that death rates have fallen…

The two COVID-19 vaccines that recently received emergency approval from the U.S. and other worldwide regulatory agencies are expected to pose little risk to the rare disease community, including to patients with compromised immune systems or those participating in gene therapy studies. That was the message of a recent…

Magnetic resonance imaging (MRI) is a better way to find pituitary tumors in Cushing’s disease than inferior petrosal sinus sampling (IPSS), according to the results of a recent record review. The study, “Lateralization of inferior petrosal sinus sampling in Cushing’s disease correlates with cavernous sinus venous drainage…

Patients with ectopic Cushing’s syndrome face challenges in their healthcare management if they live in developing countries, according to a study of cases in Colombia that describes challenges unique to the tropics. “This study may lead to the formation of groups of excellence for the management of [Cushing’s…