News

Case report: Rare PPNAD Cushing’s caused by gene duplication

An 8-year-old girl was diagnosed with primary pigmented nodular adrenocortical disease (PPNAD), a rare genetic disorder that can cause Cushing’s syndrome, a case study reports. Hers was the first reported case of PPNAD caused by a duplication in the PRKACA gene. according to the researchers. The girl’s case was described in…

Corcept trial to evaluate Cushing’s and hypertension

  A clinical trial aims to assess the prevalence of Cushing’s syndrome in adults with hard-to-treat high blood pressure. The trial, called MOMENTUM (NCT06829537), plans to recruit 1,000 adults with hypertension (high blood pressure) that remains uncontrolled despite the use of at least three different types of medications designed…

Tumors producing ACTH and CRH can complicate Cushing’s diagnosis

In rare cases, Cushing’s syndrome can be caused by tumors that are simultaneously producing two signaling molecules called adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH). Diagnosing Cushing’s in these cases can be complex, leading to delays in treatment and worse outcomes for patients, according to a new report. “Studies…

Bone tissue death successfully treated in man, 71, with Cushing’s

A 71-year-old man with Cushing’s disease developed avascular necrosis in the hips and shoulders, a condition in which bone tissue dies due to lack of blood supply, a U.S. case study reports. His Cushing’s symptoms, including avascular necrosis in the hips, were successfully managed with surgery to remove the…