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ACBP protein links cortisol to Cushing’s symptoms: Mouse study

A protein called ACBP mediates the relationship between elevated levels of cortisol, the hallmark feature of Cushing’s syndrome, and the development of associated symptoms, according to a mouse study led by researchers in France. Using several methods to suppress ACBP activity, the researchers abolished Cushing’s signs in the mice —…

Cushing’s patients have soft bones, even after remission: Study

People with Cushing’s syndrome have soft bones, even after being in remission for a long time, a study reported. Despite having comparable bone mineral density, a standard measure of bone health based on its mineral content, Cushing’s patients in remission scored significantly lower on the material strength index (BMSi), an…

ACTH-producing thymus tumor is ectopic Cushing’s syndrome’s cause

Ectopic Cushing’s syndrome in a 10-year-old girl that was caused by a thymus tumor was effectively managed with ketoconazole and surgery to remove the thymus, according to a case report from the Czech Republic. “This case presents some unique challenges related to the diagnosis, management, and treatment of thymic…

Brain structure changes may explain Cushing’s cognitive issues

People with Cushing’s disease frequently experience cognitive and psychiatric complications, often persisting after surgery to remove the disease-driving tumor, a review study noted. That could be because high cortisol levels during active phases of Cushing’s disease can cause physical changes in brain structure that persist after cortisol levels are…

Isturisa managed severe Cushing’s due to advanced adrenal cancer

A 70-year-old woman in the U.S. with Cushing’s syndrome due to advanced adrenal gland cancer who was effectively managed with Isturisa (osilodrostat) was the subject of a report by researchers. After the woman developed adrenal insufficiency, which is when the adrenal glands become unable to produce sufficient amounts of…

Woman’s glucocorticoid-induced Cushing’s syndrome misdiagnosed

A woman developed therapy-related Cushing’s syndrome after prolonged treatment with a glucocorticoid for osteoarthritis, which is marked by joint damage and degeneration, a case study reports. As a result, the woman developed adrenal insufficiency and was misdiagnosed with perimenopause. In adrenal insufficiency, the adrenal glands become unable to produce sufficient…