Serious infections requiring hospitalization remain a long-term concern in Cushing’s syndrome, even after the disease goes into remission, according to a real-world study that followed more than 600 patients for about 13 years. Researchers found that adults with Cushing’s syndrome were more than twice as likely as matched people without…
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Although rare, researchers say that recurrent Cushing’s disease can be caused by tumor cells accidentally left in the sphenoid sinus — an air-filled space behind the nose — during surgery to remove a tumor from the brain’s pituitary gland through the nasal passages. That’s what happened to a young…
Corcept Therapeutics has resubmitted its application to the U.S. Food and Drug Administration (FDA) seeking approval of relacorilant to treat endogenous Cushing’s syndrome, with new analyses as requested by the agency. The company submitted its initial new drug…
An 18-month-old girl developed treatment-related Cushing’s syndrome after prolonged use of a high-potency topical steroid cream prescribed for diaper rash, according to a recent case report. The parents had sought treatment after the toddler gained about 6 kg, or slightly more than 13 pounds, over three months. The child also…
Lundbeck’s experimental therapy, asedebart, brought cortisol levels back to normal in most adults with Cushing’s disease and was generally well tolerated when given as an intravenous (into-the-vein) infusion, according to preliminary data from the first part of an ongoing Phase 2 clinical trial. The BalanCeD (NCT06471829) study,…
Treatment with Korlym (mifepristone) may help lower blood sugar and promote weight loss in people with hard-to-control diabetes and high cortisol levels who are also taking medications targeting GLP-1, according to a new analysis of data from dozens of patients in the CATALYST clinical trial. Corcept Therapeutics, the…
Crinetics Pharmaceuticals, along with several patient groups, has launched the Everyday Advocacy initiative to help people with Cushing’s syndrome and other endocrine, or hormone-related, conditions better understand their diseases and take an active role in their care. Developed with input from several advocacy partners — including the…
Mutations in the USP8 gene appear to switch on a signaling pathway, called Sonic Hedgehog (SHH), in pituitary tumors that cause Cushing’s disease, according to a study involving patient tumor data and laboratory cell experiments. These results suggest that targeting this pathway could help guide future treatment research for patients…
After an unrelated medical exam revealed a mass on a man’s right adrenal gland, further testing showed his symptoms were actually caused by Cushing’s disease, rooted in a small pituitary tumor in the brain, according to a case report. The case highlights the need for careful testing to find…
A Moroccan woman with Cushing’s syndrome caused by prolonged exposure to glucocorticoids was unexpectedly found to also have Cushing’s disease, the form driven by a tumor in the brain’s pituitary gland, a case report shows. After stopping treatment with glucocorticoids, also commonly called corticosteroids or steroids, her cortisol levels…
Recent Posts
- Cushing’s syndrome greatly raises risk of hospitalization for infections
- Tumor cells left behind in surgery can cause Cushing’s recurrence, per report
- Building strength, even with Cushing’s, so I can be there for my daughter
- Corcept gives FDA new relacorilant data in resubmitted application
- Toddler develops Cushing’s syndrome from topical steroid use
- Seeing is believing: How Cushing’s disease affects my vision
- Asedebart normalizes cortisol levels in most Cushing’s patients: Data
- My Cushing’s disease brain fog has a mind of its own
- Korlym improves results for diabetes patients taking GLP-1 drugs
- New ‘Everyday Advocacy’ initiative supports Cushing’s syndrome care