Margarida Maia, PhD, science writer —

A 71-year-old woman developed cyclic Cushing’s syndrome, where periods of hypercortisolism alternate with periods of normal or low cortisol levels, as the result of a pheochromocytoma, a rare type of tumor that forms in the adrenal glands atop the kidneys. Cushing’s syndrome is due to high cortisol levels, or…

Sparrow Pharmaceuticals’ oral small molecule SPI-62, now being called clofutriben, can lower the levels of free cortisol in the urine of people with Cushing’s syndrome caused by a tumor outside the adrenal glands, including those with Cushing’s disease. Unlike other cortisol-lowering medications, which require careful dosing to prevent…

People with Cushing’s syndrome, including those with Cushing’s disease, appear to have more heart issues — like poorer heart function and larger ventricles, which are the heart’s lower chambers — compared with other patients with similar cardiovascular risk factors, a study using MRI imaging has found. The heart issues…

The presence of somatic mutations in the USP8 gene, found in up to half of people with Cushing’s disease, appears to have no impact on how well patients fare after undergoing surgery to remove a disease-causing pituitary tumor, a study has found. However, patients with USP8 mutations — all…

For people who undergo surgery to treat Cushing’s disease or other forms of endogenous Cushing’s syndrome, replacement treatment with glucocorticoids may not be necessary immediately before or after the procedure, a study suggests. Rather, findings favored “withholding perioperative glucocorticoids until the first postoperative day (or even longer),” the researchers…

Doctors should suspect Cushing’s syndrome when they see patients with purple stretch marks and metabolic conditions such as diabetes, even if those symptoms aren’t the reasons for a medical visit, physicians in Japan wrote in a case study describing how they reached that diagnosis for a woman in her early…

About 1 in 4 people with Cushing’s syndrome caused by a tumor saw their symptoms come back after undergoing surgery to remove the tumor, a new study found. People with Cushing’s disease, which is caused by a pituitary tumor, saw their tumors recur sooner than did those whose…

In 2023, Cushing’s Disease News brought readers comprehensive coverage of the latest scientific research and developments in treatment for Cushing’s disease. Here are the 10 most-read news stories of 2023, along with a brief description of each. We look forward to continuing to serve as a resource for…

Accurately locating tumors in the brain’s pituitary gland by inferior petrosal sinus sampling or IPSS — an invasive test that’s been considered the gold standard for diagnosing Cushing’s disease — may not necessarily lead to better outcomes after surgery, according to a new meta-analysis. While IPSS correctly determined…

For a woman in her 60s in China, Cushing’s syndrome led to a myocardial infarction or heart attack, and to heart failure, according to a report on the rare case. The patient’s Cushing’s was secondary to an adrenocortical adenoma — a benign, or non-cancerous, tumor that formed in the…