Andrea Lobo,  —

A higher volume of epicardial adipose tissue (EAT) — meaning more fat accumulated near the heart muscle and arteries that supply the heart — significantly increases the risk for early heart disease in people with Cushing’s syndrome. That’s according to a study from China that assessed risk factors for left…

Treatment with Isturisa (osilodrostat) is generally well tolerated and effective at reducing cortisol levels and easing Cushing’s disease symptoms in Asian patients, with results similar to those seen in non-Asian patients. That’s according to a new study that compared both patient populations in two Phase 3 clinical trials…

A rare, highly malignant kidney tumor turned out to be the cause of Cushing’s syndrome in an 18-year-old man whose case was described in a recent study. The man had classic symptoms of Cushing’s, including weight gain, fat buildup, and skin changes that resolved after the kidney harboring the…

A new report from researchers at the Montefiore Medical Center in New York details the cases of two women with ectopic Cushing’s secondary to diffuse idiopathic neuroendocrine cell hyperplasia, or DIPNECH — a rare lung disease that may lead to the development of tumors that in extremely rare cases may…

A low-dose dexamethasone test, which is commonly used to diagnose Cushing’s syndrome, can effectively detect the rare condition in people with obesity, according to a new study. However, despite the test’s effectiveness, the proportion of patients who ultimately were diagnosed with Cushing’s was low, at 0.2%. Given that finding,…

In what researchers describe as an “exceedingly rare” case, adrenocorticotropic hormone (ACTH)-producing advanced adrenal gland cancer was determined to be the cause of Cushing’s syndrome in a 26-year-old woman in Portugal. Adrenocortical carcinoma is typically associated with ACTH-independent Cushing’s — forms of the syndrome in which excessive cortisol production is…

The rare case of a 14-year-old girl who experienced spontaneous remission of Cushing’s disease after pituitary tumor apoplexy has been reported by researchers in South America. Pituitary apoplexy, or PA, is a rare and potentially life-threatening condition caused by bleeding or infarction (cell death due to impaired blood flow)…

An invasive tumor in the thymus turned out to be the cause of a 31-year-old woman’s severe ectopic, adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, according to a case recently reported in Poland. As initial imaging scans failed to detect the thymus lesion, a tumor in the left adrenal gland was suspected…

Mutations in the USP8 gene are found in 35% of the pituitary corticotroph adenomas that cause Cushing’s disease, and more commonly affect women than men, a review study found. Thus, targeting the gene and epidermal growth factor receptor (EGFR) — whose levels are increased in patients with USP8 mutations…

A protein found in tissues that produce and release hormones may be a biomarker to help distinguish Cushing’s disease from adrenocorticotropic hormone (ACTH)-dependent ectopic Cushing’s. That’s according to a recent study in Japan that also reported that chromogranin A was higher in people with ACTH-dependent ectopic Cushing’s than those…