News

The presence of somatic mutations in the USP8 gene, found in up to half of people with Cushing’s disease, appears to have no impact on how well patients fare after undergoing surgery to remove a disease-causing pituitary tumor, a study has found. However, patients with USP8 mutations — all…

A technique called trabecular bone score, or TBS, may be better at assessing bone damage and loss than bone mineral density, the current gold standard, in successfully treated patients with Cushing’s disease, according to a recent study. High cortisol levels characterize Cushing’s, and they are known to increase the…

A 44-year-old woman was found to have a hormone-producing tumor in her left adrenal gland, which produced and released both cortisol and testosterone, leading to the onset of Cushing’s syndrome. The high levels of testosterone produced and released by the tumor also caused her to develop virilization, a condition in…

For people who undergo surgery to treat Cushing’s disease or other forms of endogenous Cushing’s syndrome, replacement treatment with glucocorticoids may not be necessary immediately before or after the procedure, a study suggests. Rather, findings favored “withholding perioperative glucocorticoids until the first postoperative day (or even longer),” the researchers…

Among people with Cushing’s syndrome who enter into remission, women appear to be more likely than men to develop certain new conditions, including autoimmune disorders, within one year. That’s according to the findings of a systematic literature review done by researchers who reported on the case of a 42-year-old man…

About five months of treatment with relacorilant significantly reduced both high blood pressure and high blood sugar levels in people with endogenous Cushing’s syndrome, according to data from a Phase 3 trial. Relacorilant also was found to be generally safe and well tolerated, and to be able to significantly…

A 66-year-old woman in South America was diagnosed with Cushing’s disease after being referred for a consultation with a specialist for obesity associated with pain and reduced mobility in the right knee, according to a new case study. Titled “From Knee Pain Consultation to Pituitary Surgery: The Challenge…

Changes in blood flow linked to obesity start in the early stages of Cushing’s disease, as evidenced by a significant decrease in the blood-pumping ability of the heart, a new study reported. While obese patients appeared to have normal heart function in standard echocardiographic examinations, a noninvasive method called…

A rare type of nasal tumor, called olfactory neuroblastoma, caused ectopic Cushing’s syndrome in a 47-year-old man, as described in a recent case report. Surgical treatment led to a reduction of the patient’s blood cortisol and adrenocorticotropic hormone (ACTH) levels, which were elevated as a result of the tumor. “This…

Ubie and the Cushing’s Support and Research Foundation (CSRF) have teamed up to raise awareness and shorten the time people with Cushing’s syndrome have to wait for a diagnosis. The long-term collaboration seeks to confirm the diagnostic capacity of Ubie’s free, artificial intelligence (AI)-powered platform called Symptom…