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A 46-year-old man with Cushing’s disease in the U.S. lacked many of the typical symptoms due to impairments in the activity of an enzyme called 11 beta-hydroxysteroid dehydrogenase type 1 (HSD-1), according to a recent case report. HSD-1 is needed for cells to convert cortisone, an inactive form of…

Yana Zavros, PhD, a physiologist working on Cushing’s disease, has been named the Georgia Research Alliance’s eminent scholar in molecular medicine. She will establish and direct a new research center at the University of Georgia’s School of Medicine, focusing on translating laboratory observations into clinical practice. The center will…

Lack of patient-centered care, dismissing symptoms, and negative experiences related to changes in weight may delay recognizing and diagnosing Cushing’s syndrome by primary healthcare providers, a study that gathered the experiences and perceptions of seven women in Canada suggests. “Overall, the results of our study highlight the importance of…

High blood-sugar levels and osteoporosis — a condition causing bones to weaken and be prone to fracture — are more common in men with ectopic Cushing’s syndrome than women, who are more likely to have high blood pressure, a Turkish study reports. “Apart from these, the lack of sex differences,…

The rare case of an 18-year-old woman with ectopic Cushing’s syndrome due to a neuroendocrine lung tumor — a rare tumor that may cause Cushing’s — was described by researchers at the Icahn School of Medicine at Mount Sinai in New York. The patient was successfully treated by surgically removing…

Sleep quality markedly improves for people with endogenous Cushing’s syndrome after treatment leads to disease remission, but nearly half of these patients continue to experience sleep disturbances. Those are the findings of a single-center study in the U.S. that also demonstrated that the proportion of Cushing’s patients taking medications for…

A higher volume of epicardial adipose tissue (EAT) — meaning more fat accumulated near the heart muscle and arteries that supply the heart — significantly increases the risk for early heart disease in people with Cushing’s syndrome. That’s according to a study from China that assessed risk factors for left…

The rare case of a 6-month-old girl in India who developed ectopic Cushing’s syndrome due to a cancerous tumor in her right hip was described in a new study. After completing two rounds of chemotherapy and undergoing surgery, the girl recovered normal functioning in her hypothalamic-pituitary-adrenal axis, which controls cortisol…

Women with Cushing’s syndrome may be misdiagnosed with fibromyalgia — a chronic condition characterized by widespread pain and mental distress — despite showing Cushing’s symptoms, a new case series report demonstrates. The researchers say these misdiagnoses of fibromyalgia, occurring in a trio of Cushing’s syndrome patients across three…

Treatment with Isturisa (osilodrostat) is generally well tolerated and effective at reducing cortisol levels and easing Cushing’s disease symptoms in Asian patients, with results similar to those seen in non-Asian patients. That’s according to a new study that compared both patient populations in two Phase 3 clinical trials…