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A woman in the U.K. with Cushing’s disease was successfully treated with Isturisa (osilodrostat), which helped lower her cortisol levels to normal and later allowed doctors to clearly identify her pituitary tumor on an MRI scan for surgical removal. If validated, “this approach could refine surgical planning and…

A diagnostic test using desmopressin, an artificial form of a naturally occurring hormone, successfully detected a residual pituitary tumor after surgery to treat a woman with cyclic Cushing’s disease when standard tests failed, a case study reports. The researchers noted that the very nature of cyclic Cushing’s disease —…

Researchers have developed an online tool — called CuPeR — that can accurately predict the persistence or recurrence of Cushing’s disease following surgery to remove the disease-causing pituitary tumor, a study reports. From patient data, four clinical factors were identified as predictors of postoperative outcomes: tumor site, prior…

Cyclic Cushing’s disease — where bouts of high cortisol levels come and go — can be safely and effectively managed with Isturisa (osilodrostat) when surgery isn’t an option, according to a new case report from researchers in California. The report detailed the case of a man in his…

After undergoing surgery to remove a pituitary tumor, people with Cushing’s disease face the highest risk of developing dangerous blood clots, a new study has found. This heightened risk — specifically of a complication called deep vein thrombosis (DVT) — is tied to factors such as age, body mass index,…

Researchers have confirmed a relationship between increasing doses of Isturisa (osilodrostat) and decreasing levels of cortisol in the bloodstream of adults with Cushing’s disease and other forms of Cushing’s syndrome, according to a study report. Within one hour of Isturisa intake, patients’ blood cortisol reached the lowest levels,…

People with Cushing’s syndrome who are immunosuppressed due to high cortisol levels, or hypercortisolism, may be at risk for rare asymptomatic infections, according to a recent case report. A man diagnosed with Cushing’s syndrome tested positive for the Rhodococcus bacteria, but he didn’t have any symptoms of an infection…

In recent years, fewer people are presenting with classic features of Cushing’s disease, such as moon face and purple stretch marks, according to a three-decade analysis of disease management. Patients diagnosed more recently are also older, and they have lower levels of cortisol and smaller pituitary tumors than those…

Transsphenoidal surgery, a minimally invasive procedure to remove pituitary tumors through the nose, achieved long-term remission in nearly all children with Cushing’s disease who participated in a single-center study in China. “While recurrence occurred in a minority of patients, primarily those with [small tumors], durable disease control is attainable for…

About half of people with Cushing’s disease have abnormalities in their adrenal glands, the small organs above the kidneys that make cortisol, a new study from Israel has found. Further, small growths in the adrenal tissue — called adrenal nodules — occurred about 10 times more often in these…