News

A common diagnostic test for Cushing’s disease can fail to detect the condition in nearly 10% of patients, according to new research that suggests these “atypical” results may signal a more aggressive form of the disorder. The study found that patients who respond unusually to the test are significantly…

Weak bones and fragility fractures are highly prevalent among people with Cushing’s syndrome, a risk that persists even after achieving disease remission, according to a medical records analysis. Despite these findings, less than half of this patient population had their bone health properly assessed and/or managed, the data showed. “These…

Surgery is usually successful for bringing Cushing’s disease into remission, and most patients do not experience any problems — but nonetheless, serious and even fatal complications are possible, and surgery isn’t effective for all individuals with the disease. Those are the findings of a new study from the U.K.

Isturisa (osilodrostat) is now available in Canada for adults with Cushing’s disease who have persistent or recurrent high cortisol after pituitary surgery and/or pituitary irradiation, or who can’t have pituitary surgery, according to Recordati Rare Diseases Canada. The oral medication is approved in the U.S. and the European…

The corticotropin-releasing hormone (CRH) stimulation test is a reliable tool for diagnosing Cushing’s disease, according to a recent study. Results show that its accuracy is comparable to that of bilateral inferior petrosal sinus sampling (BIPSS), the gold standard but invasive method, in distinguishing Cushing’s disease from ectopic Cushing’s syndrome.

A woman with type 1 diabetes was diagnosed with Cushing’s disease after her daily insulin needs rose sharply and no longer controlled her blood sugar levels, a case study reports. “This case underscores the importance of regular review of automated insulin delivery data and consideration of [hormonal] causes of…

A diagnostic test using an artificial form of the naturally occurring hormone desmopressin could be a good alternative to the standard test used to diagnose Cushing’s disease in children and adolescents, according to a study. Researchers found that the accuracy of the desmopressin stimulation test (DDAVP) was comparable to…

Although acinic cell carcinoma — a cancer of the glands that produce saliva — is usually considered low risk, it can behave aggressively and cause Cushing’s syndrome, according to researchers who described such a case involving a 58-year-old man in Turkey. They added that if not recognized and treated…

The U.S. Food and Drug Administration (FDA) has declined to approve relacorilant, an experimental oral therapy for patients with Cushing’s syndrome experiencing high blood pressure. In a complete response letter, the agency stated that current data do not yet conclusively show that the treatment’s benefits outweigh its risks. The…

Treatment with Isturisa (osilodrostat) normalized cortisol levels in most people with ectopic Cushing’s syndrome, including those with severe disease, according to real-world data from Spain. Normal cortisol levels were reached within a month of starting treatment in more than a third of patients (36%). “Therefore, [Isturisa] should be considered…