Mutations in the USP8 gene appear to switch on a signaling pathway, called Sonic Hedgehog (SHH), in pituitary tumors that cause Cushing’s disease, according to a study involving patient tumor data and laboratory cell experiments. These results suggest that targeting this pathway could help guide future treatment research for patients…
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After an unrelated medical exam revealed a mass on a man’s right adrenal gland, further testing showed his symptoms were actually caused by Cushing’s disease, rooted in a small pituitary tumor in the brain, according to a case report. The case highlights the need for careful testing to find…
A Moroccan woman with Cushing’s syndrome caused by prolonged exposure to glucocorticoids was unexpectedly found to also have Cushing’s disease, the form driven by a tumor in the brain’s pituitary gland, a case report shows. After stopping treatment with glucocorticoids, also commonly called corticosteroids or steroids, her cortisol levels…
Improvements in quality of life after successful surgery for Cushing’s disease vary widely, with many patients continuing to struggle physically and emotionally in the months following treatment despite normalization of cortisol levels, a new study has found. “Our results highlight the need to educate and support patients before and…
Japan’s Ministry of Health, Labour and Welfare has granted orphan drug designation to Lundbeck’s asedebart, an investigational therapy for Cushing’s disease and congenital adrenal hyperplasia (CAH), two conditions characterized by excessive production of adrenocorticotropic hormone. This regulatory status is intended to support the development of medicines for serious rare…
A father and daughter who carried the same genetic variant both developed Cushing’s disease, according to a recent report. Both underwent pituitary surgery through the nose, called an endoscopic endonasal approach, followed by glucocorticoid replacement therapy, and both remain in biochemical remission. Researchers still do not know whether the…
Abnormal protein levels in the blood that develop during Cushing’s disease may somewhat, but not entirely, normalize when disease activity resolves, a new study reports. These “distinct [blood] protein profiles” could potentially indicate an “increased risk for thrombosis [formation of a blood clot inside a blood vessel] and metabolic…
A rare lung neuroendocrine tumor was linked to both Cushing syndrome and acromegaly, a disorder marked by enlarged hands and feet, in a 43-year-old woman in India, according to a case report. The tumor produced adrenocorticotropic hormone (ACTH), which led to Cushing syndrome. Findings also suggested growth hormone-releasing…
Even after people with Cushing’s syndrome achieve remission, the inflammatory activity of certain immune cells is increased, according to a new study. The findings may help to explain data suggesting that Cushing’s patients in remission are at higher risk of certain autoimmune and inflammatory disorders, researchers said. The study, “Increased…
Pregnant women with Cushing’s syndrome and uncontrolled high levels of cortisol, a naturally occurring steroid hormone, may have a greater risk of developing high blood pressure and diabetes, and their babies are more likely to be born early. That’s according to the findings of a systematic review and meta-analysis of…
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