People with Cushing’s syndrome may continue to have excess abdominal fat and diabetes years after achieving disease remission, putting them at an increased risk of experiencing cardiovascular, or heart-related, problems, a new study from Europe found. The data showed that, seven years after remission, individuals who’d had Cushing’s were more…
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An exceptionally small pituitary tumor caused severe Cushing’s disease in a young man, leading doctors to take an unusual treatment approach after determining the disease-causing microadenoma would be too difficult to remove surgically, according to a case report from Iraq. Instead of surgery — the standard treatment for…
People with Cushing’s syndrome may experience lasting fatigue, reduced work ability, and disability years after treatment, including during remission, a new study shows. Researchers found that people with both active Cushing’s and disease in remission reported poor work ability. Among those in remission, fatigue and disability were also common, showing…
Japanese children with Cushing’s disease often went years before receiving a diagnosis, but surgery led to remission in most of those with outcome data. Measures of growth and body mass index also improved during follow-up, a study suggests. Researchers noted that although the…
Long-term use of corticosteroids may cause iatrogenic Cushing’s syndrome, a side effect of the medication that can lead to noticeable changes such as a rounded, “moon-shaped” face, according to a case report from India. In the report describing five patients, all but one…
Serious infections requiring hospitalization remain a long-term concern in Cushing’s syndrome, even after the disease goes into remission, according to a real-world study that followed more than 600 patients for about 13 years. Researchers found that adults with Cushing’s syndrome were more than twice as likely as matched people without…
Although rare, researchers say that recurrent Cushing’s disease can be caused by tumor cells accidentally left in the sphenoid sinus — an air-filled space behind the nose — during surgery to remove a tumor from the brain’s pituitary gland through the nasal passages. That’s what happened to a young…
Corcept Therapeutics has resubmitted its application to the U.S. Food and Drug Administration (FDA) seeking approval of relacorilant to treat endogenous Cushing’s syndrome, with new analyses as requested by the agency. The company submitted its initial new drug…
An 18-month-old girl developed treatment-related Cushing’s syndrome after prolonged use of a high-potency topical steroid cream prescribed for diaper rash, according to a recent case report. The parents had sought treatment after the toddler gained about 6 kg, or slightly more than 13 pounds, over three months. The child also…
Lundbeck’s experimental therapy, asedebart, brought cortisol levels back to normal in most adults with Cushing’s disease and was generally well tolerated when given as an intravenous (into-the-vein) infusion, according to preliminary data from the first part of an ongoing Phase 2 clinical trial. The BalanCeD (NCT06471829) study,…
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