An 8-year-old girl was diagnosed with primary pigmented nodular adrenocortical disease (PPNAD), a rare genetic disorder that can cause Cushing’s syndrome, a case study reports. Hers was the first reported case of PPNAD caused by a duplication in the PRKACA gene. according to the researchers. The girl’s case was described in…
Treatment with mesenchymal stem cells, a type of adult stem cell, was shown to reduce the levels of low-density lipoprotein (LDL) cholesterol — known as bad cholesterol — in a mouse model of exogenous Cushing’s syndrome, according to a study conducted in South Korea. The researchers noted that exogenous Cushing’s,…
A protein called ACBP mediates the relationship between elevated levels of cortisol, the hallmark feature of Cushing’s syndrome, and the development of associated symptoms, according to a mouse study led by researchers in France. Using several methods to suppress ACBP activity, the researchers abolished Cushing’s signs in the mice —…
People with Cushing’s syndrome have soft bones, even after being in remission for a long time, a study reported. Despite having comparable bone mineral density, a standard measure of bone health based on its mineral content, Cushing’s patients in remission scored significantly lower on the material strength index (BMSi), an…
A 75-year-old woman with Cushing’s disease who was first seen with marked weight loss and low blood levels of potassium, or hypokalemia, was described by researchers as an unusual example of the condition, one otherwise resembling ectopic Cushing’s syndrome. “This case highlights the need to entertain a broad differential…
High levels of cortisol in the bloodstream of people with Cushing’s syndrome were directly linked to significant metabolic abnormalities leading to the buildup of fat deposits in the liver, according to a new study from researchers in China. The researchers noted that liver fat accumulation increases a person’s risk of…
A diagnostic test using desmopressin, an artificial form of a naturally occurring hormone, can help to accurately identify people with Cushing’s disease, a study reports. Easier than the current gold standard for diagnosing this disease, the desmopressin stimulation test might “reduc[e] the reliance on invasive procedures and provid[e] a…
People often do not recognize the typical symptoms and features of Cushing’s syndrome, regardless of their severity, which contributes to a delay in diagnosis, a study found. Moreover, there was a discrepancy between the number of symptoms reported by individuals with Cushing’s and those assessed by clinicians — with…
Lundbeck has launched a Phase 2 clinical trial to assess the efficacy, safety, and tolerability of Lu AG13909, a potential first-in-class treatment for Cushing’s disease. “We are pleased to advance this new approach to potentially treating unmet needs in Cushing’s disease, a condition that, when uncontrolled, is debilitating…
Blood levels of cortisol or adrenocorticotropic hormone (ACTH) measured one day after pituitary tumor removal surgery independently predicted Cushing’s disease remission after one year, according to a real-world study. Post-surgical remission rates were higher among adults after a first surgery compared with those seen for patients who underwent a second…
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