Genetic testing showed that a woman with a recurrent pituitary tumor causing Cushing’s disease had Lynch syndrome due to a mutation in the MSH6 gene — the second known case in which the syndrome may have triggered Cushing’s, according to a case report. Lynch syndrome is an inherited condition caused by…
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Artificial intelligence (AI) tools may help predict which people with Cushing’s disease are likely to achieve remission after surgery, according to a new systematic review and meta-analysis. To evaluate how accurately AI can forecast remission outcomes, a team of researchers from the U.S., Iran, and Australia analyzed results from five…
Stereotactic radiosurgery (SRS), a targeted form of radiation that precisely delivers high doses to tumors while sparing surrounding tissue, may be a safe and effective treatment to control hard-to-treat Cushing’s disease, according to a meta-analysis of published studies. SRS induced biochemical remission in about two-thirds of cases…
Bone complications are frequent in people with Cushing’s syndrome, including those with Cushing’s disease, but are not consistently assessed or treated across Europe, according to a large study. The findings, based on data from nearly 1,700 patients, showed that osteoporosis — a condition marked by fragile bones — and…
The blood-thinning medication rivaroxaban was safe and effective at preventing the formation of blood clots in deep veins or the lungs, known as venous thromboembolism (VTE), in people with adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, according to a recent study. The study demonstrated that the treatment prevented both new and recurrent…
Among adults with Cushing’s syndrome caused by tumors in both adrenal glands, surgery to remove the tumors led to the best cortisol control and the most favorable outcomes, according to a large international study. However, the risk of death and the rates of cardiovascular events were similar across different treatment…
A common diagnostic test for Cushing’s disease can fail to detect the condition in nearly 10% of patients, according to new research that suggests these “atypical” results may signal a more aggressive form of the disorder. The study found that patients who respond unusually to the test are significantly…
Weak bones and fragility fractures are highly prevalent among people with Cushing’s syndrome, a risk that persists even after achieving disease remission, according to a medical records analysis. Despite these findings, less than half of this patient population had their bone health properly assessed and/or managed, the data showed. “These…
Surgery is usually successful for bringing Cushing’s disease into remission, and most patients do not experience any problems — but nonetheless, serious and even fatal complications are possible, and surgery isn’t effective for all individuals with the disease. Those are the findings of a new study from the U.K.
Isturisa (osilodrostat) is now available in Canada for adults with Cushing’s disease who have persistent or recurrent high cortisol after pituitary surgery and/or pituitary irradiation, or who can’t have pituitary surgery, according to Recordati Rare Diseases Canada. The oral medication is approved in the U.S. and the European…
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