News

Case of exogenous Cushing’s tied to accidental use of glucocorticoid

A 66-year-old woman developed exogenous Cushing’s syndrome — when the disease is unintentionally caused by medications — after accidentally taking a glucocorticoid prescribed for her husband, according to a case report. Exogenous Cushing’s syndrome is the most common form of the condition, but usually is triggered by the use…

Urgent response advised for Cushing’s due to pancreatic tumors

Two unusual cases of Cushing’s syndrome caused by pancreatic tumors that had spread to the liver were described in a recent report, highlighting the importance of assessing the presence of Cushing’s in people with pancreatic tumors who continue to show signs of the disorder. The disorder, called ectopic ACTH syndrome…

Doctors see Cushing’s symptoms as considerable, favor better therapies

A survey of U.S. doctors treating people with Cushing’s syndrome noted a considerable burden of symptoms, ranging from fatigue to muscle weakness, that weigh on patients’ life quality and personal finances, and a need for better treatments. These endocrinologists  — physicians who specialize in disorders affecting hormone-producing glands — also…

High cortisol levels, being male raise risk of blood clots

Being male, having high cortisol levels at the time of Cushing’s diagnosis, and undergoing multiple surgeries were identified as key factors linked to a high risk of blood clots in people with Cushing’s, according to data from a large European registry. Preventive anti-blood clotting protocols varied across treatment centers,…

More biomarkers needed to support Cushing’s syndrome diagnosis

More biomarkers are necessary for the differential diagnosis of Cushing’s syndrome subtypes in children and adolescents, as well as to predict disease progression more effectively — allowing for quicker and less invasive assessments of patients. That’s according to the results of a new, large, observational study, which also reported on…

Diabetes med metformin studied as Cushing’s treatment

Metformin, a medicine used mostly to treat type 2 diabetes, eased the signs of Cushing’s disease in cells and in a mouse model, a study showed. “These findings suggest metformin as a potential drug for the treatment of Cushing’s disease,” researchers wrote in the study, “Metformin…

Ectopic Cushing’s tied to rare yolk sac tumor in pancreas

A 27-year-old woman in China has become the first reported case of an adult developing ectopic Cushing’s syndrome as a result of a rare yolk sac tumor in the pancreas producing high levels of adrenocorticotropic hormone (ACTH) precursors, according to researchers. A yolk sac tumor is a rare, malignant tumor…

Top 10 Cushing’s disease stories of 2023

In 2023, Cushing’s Disease News brought readers comprehensive coverage of the latest scientific research and developments in treatment for Cushing’s disease. Here are the 10 most-read news stories of 2023, along with a brief description of each. We look forward to continuing to serve as a resource for…

Locating tumors by IPSS may not lead to better surgery outcomes

Accurately locating tumors in the brain’s pituitary gland by inferior petrosal sinus sampling or IPSS — an invasive test that’s been considered the gold standard for diagnosing Cushing’s disease — may not necessarily lead to better outcomes after surgery, according to a new meta-analysis. While IPSS correctly determined…