News

Woman with Cushing’s seen with rare digestive tract perforation

A woman with Cushing’s syndrome developed an ulcer that caused a gastrointestinal perforation, or a hole in the digestive tract, according to a case study. Because she had no established risk factors for such a complication, researchers suggested prolonged exposure to high levels of cortisol, or hypercortisolism, may have contributed…

Surgery can partially restore certain brain networks in Cushing’s

Surgery can partially reverse functional impairments in brain networks in people with Cushing’s disease after three months, when their cortisol levels return to normal, according to a recent study. Researchers say elevated cortisol levels in patients with active disease are linked to connectivity impairments in three large-scale functional brain…

Ectopic Cushing’s tied to recurring blood clots in woman’s lungs

The unusual case of a woman with Cushing’s syndrome caused by an adrenal tumor who experienced recurring episodes of blood clots in the lungs was described in a recent report. The study, “Adrenocorticotropic hormone-secreting phaeochromocytoma as a cause of treatment-resistant hypertension and recurrent pulmonary emboli,” was published…

BIPSS can reliably diagnose Cushing’s after inconclusive tests

A recent study supports the reliability of a diagnostic tool to distinguish adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome in people who have inconclusive imaging or biochemical test results. The procedure, called bilateral inferior petrosal sinus sampling (BIPSS), is able to accurately differentiate patients with Cushing’s disease from…

Signifor with cabergoline may aid persistent Cushing’s disease

Patients with persistent Cushing’s disease may benefit from combining Signifor (pasireotide) with cabergoline, according to the findings of a Phase 2 clinical trial. The results suggest the combo therapy “could be an effective long-term strategy for enhancing the control of CD [Cushing’s disease]” in patients who fail to respond or…