Rare Diseases Constitute a ‘Public Health Issue,’ NCATS Director Warns
With 250 rare diseases newly identified every year, scientists can barely keep up — even as the healthcare system fails millions of Americans whose ... Read more
Updates
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Signifor Normalizes Cortisol Levels in Cushing’s Disease Patients, Real-world Study Shows
In real-life clinical practice, Novartis‘ Signifor (pasireotide) completely or nearly normalizes the levels of cortisol in the urine of patients with mild to moderate ... Read more -
Strongbridge Prepares to Submit New Drug Application for Recorlev
Strongbridge Biopharma is preparing the submission of a New Drug Application (NDA) with the U.S. Food and Drug Administration (FDA) seeking the approval of Recorlev ... Read more -
Metoclopramide Can Mask Adrenal Insufficiency After Gland Removal in BMAH Patients, Case Report Suggests
Metoclopramide, a gastrointestinal medicine, can increase cortisol levels after unilateral adrenalectomy — the surgical removal of one adrenal gland — and conceal adrenal insufficiency ... Read more -
Strongbridge’s Recorlev Alleviates Symptoms of Cushing’s Syndrome, Eases Depression, Study Shows
Strongbridge Biopharma’s Recorlev (levoketoconazole) alleviates clinical signs and symptoms of Cushing’s syndrome that may cause discomfort and distress to patients, a Phase 3 trial shows. ... Read more
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Mifepristone May Help Prevent Adrenal Insufficiency After Adrenalectomy, Rat Study Suggests
Mifepristone, a medicine that blocks glucocorticoid hormone effects, may be useful for preventing adrenal ... -
Nonprofit Group Works to Raise Rare Disease Awareness in India
With an estimated 1.37 billion inhabitants, India will likely surpass China in five years ... -
Endogenous Cushing’s Syndrome Patients Sought for Phase 3 Trial Testing Relacorilant
Corcept Therapeutics is recruiting participants for its Phase 3 clinical trial evaluating relacorilant as ... -
Cortisol, ACTH Levels Identify Patients at Risk of Low Blood Potassium After Korlym Treatment, Study Says
Serum cortisol and adrenocorticotropic hormone (ACTH) levels may be useful in identifying Cushing’s syndrome ... -
Cyclic Cortisol Production May Lead to Misdiagnosis in Cushing’s, Study Finds
Increased cortisol secretion may follow a cyclic pattern in patients with adrenal incidentalomas, a ...
Cardiovascular Health, Quality of Life Improves After Cushing’s Syndrome Surgery, Study Shows
News
Heart problems in Cushing’s syndrome patients may be partially reversed after tumor removal surgery, new research shows. For most patients in the study, the surgery also improved quality of life, mental and physical health, anxiety, and depression. However, 1 ... Read more