Lila Levinson, PhD,  Science Writer—

Children with Cushing’s disease whose pituitary tumors carry USP8 gene mutations tend to have larger, more invasive tumors and face a higher risk of persistent or recurrent disease after surgery, a study reports. While inherited mutations do not cause most pediatric cases, non-inherited mutations appear to influence tumor size…

A positron emission tomography (PET)-based imaging technique is comparable to standard MRI in its ability to find small pituitary gland tumors related to Cushing’s disease, a study reports. While both techniques correctly identified the location of the tumors, called small pituitary neuroendocrine tumors (PitNETs), for most study participants, neither…

Using precise, image-guided techniques for the delivery of radiotherapy can help control Cushing’s disease in cases where surgery to remove disease-causing tumors proves impossible or ineffective, a study reports. This type of stereotactic radiotherapy prevented further tumor growth in nearly 95% of participants and helped several reach normal levels…

A woman with an adrenal gland tumor producing cortisol, which may have progressed to Cushing’s syndrome without treatment, experienced relief from her symptoms after surgery to remove the tumor. The woman, Hanna Pierce, expressed relief that her symptoms resolved quickly after the procedure, citing improvements in her mood and energy…

A team of clinicians in China successfully diagnosed and treated a 28-year-old woman with pregnancy-complicated Cushing’s syndrome, with both mother and child making full recoveries after a Cesarian section delivery at nearly eight months’ gestation, a study reports. The obstetrical team attempted “active complication management,” but otherwise followed a…

An imaging technique developed by scientists in India may help clinicians accurately identify tumors associated with Cushing’s disease, including in cases that are difficult to diagnose with other methods, a study reports. This new method uses a novel form of positron emission tomography (PET) imaging alongside CT scans to…

A U.S. case study describes woman in remission from Cushing’s disease who later developed a different form of Cushing’s syndrome, a rare occurrence that researchers said suggests the need for recognizing that this may happen and adopting individualized treatment approaches. The woman was initially diagnosed with Cushing’s disease, a…

Individualized treatments helped two women and their babies avoid complications of Cushing’s syndrome during pregnancy, according to a case report. “Careful clinical observation during pregnancy and after delivery is necessary to initiate appropriate treatment,” the researchers wrote. Both cases were detailed in the study, “Diagnosis and Management…

A 30-year-old woman had a relapse of cyclic Cushing’s syndrome shortly after giving birth, according to a case report that researchers said underscores the importance of “long-term follow-up in patients with a high index of suspicion for cyclic [Cushing’s syndrome].” The study, “ACTH-dependent Cyclic Cushing Syndrome With…