Lindsey Shapiro, PhD,  science writer—

People with Cushing’s syndrome who are immunosuppressed due to high cortisol levels, or hypercortisolism, may be at risk for rare asymptomatic infections, according to a recent case report. A man diagnosed with Cushing’s syndrome tested positive for the Rhodococcus bacteria, but he didn’t have any symptoms of an infection…

The noncancerous pituitary gland tumors that cause Cushing’s disease can rarely become cancerous, leading to rapidly progressing disease, a recent case report highlighted. Scientists reported on two middle-aged women with Cushing’s who underwent surgery and radiation therapy for their pituitary tumors. The tumors eventually recurred and spread, showing signs…

Abnormalities in regulating blood sugar are prevalent in people with Cushing’s disease, but can be improved for many with surgery, a study finds. The data emphasize the importance of careful blood sugar monitoring before and after surgery, according to the study’s authors. The study, “The outcome of…

People with Cushing’s disease are at a higher risk for certain types of blood clots than individuals with other forms of pituitary gland tumors, a U.K. study found. Specifically, for example, the risk of clotting complications was more than 40 times higher among those with Cushing’s disease than for…

Cushing’s Awareness Day, which marks the birthday on April 8 of Harvey Cushing, becomes Cushing’s Awareness Month this year thanks to the efforts of the Cushing’s Support & Research Foundation (CSRF), which hopes to shine some light throughout the month on this group of diseases caused by excessive exposure…

Diagnosing and managing Cushing’s syndrome in children can be complex and takes careful management, according to a case report and review study that described the difficult diagnostic process for a boy who was ultimately found to have Cushing’s disease that could be managed through surgery. “Our case was illustrative…

People with Cushing’s disease have more fat in their kidneys and around the heart than those with other conditions with elevated cortisol, a study suggests. Across all the people evaluated, including those with Cushing’s syndrome, levels of these types of fat were associated with metabolic factors, such as diabetes,…

Lower urinary cortisol levels at the start of treatment with Recorlev (levoketoconazole) are associated with higher rates of cortisol normalization among people with endogenous Cushing’s syndrome, according to new analyses from a Phase 3 clinical trial. Patients with lower starting cortisol levels also require lower maintenance doses of Recorlev…

CRN04894, now being called atumelnant, quickly lowered urine cortisol levels in five people with ACTH-dependent Cushing’s syndrome taking part in a clinical trial, according to interim study findings. The open-label Phase 1b/2a trial (NCT05804669), which is being conducted at the National Institutes of Health (NIH) in Maryland, still…

Reaching a prompt diagnosis of Cushing’s syndrome and managing it appropriately during pregnancy are critical for minimizing the condition’s harmful effects on the mother and her child, according to case series that followed five women who gave birth at a clinic in Australia. The series also highlighted the challenges of…