The pituitary adenomas that cause Cushing’s disease in men differ from those in women in hormone content and gene expression patterns, a study shows. These findings suggest that biological sex may also play a role in the molecular behavior of tumors, in addition to prevalence and clinical course. A…
More than half of the people with Cushing’s syndrome due to masses in both adrenal glands have disease-causing mutations the ARMC5 gene, a small study has found, suggesting that such patients should undergo genetic analysis for this gene. The study, “Allelic Variants of ARMC5 in Patients…
Development of cyclic Cushing’s disease — a form of Cushing’s in which cortisol levels are intermittently high — may be a result of mutations in genes controlling both pituitary tumor growth and the body’s internal clock system, a case report suggests. The study, “A putative…
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