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The nonprofit RARE-X is creating an easily-accessible, centralized data hub for all rare disease patient data that can help researchers answer questions about existing disorders, discover new ones, and work toward finding treatments. It was spun out of the work that Nicole Boice, founder and chief engagement officer of…

Corcept Therapeutics is on track to ask the U.S. Food and Drug Administration (FDA) to approve the investigational therapy relacorilant to treat Cushing’s syndrome by the middle of next year, the company announced. Cushing’s syndrome is characterized by excessive levels of the stress hormone cortisol, which causes a range of…

It’s been nearly a year since the EveryLife Foundation for Rare Diseases released its expansive report finding the total economic burden of rare disorders in the U.S. to be nearly $1 trillion.

Patients with Cushing’s syndrome are almost two times more likely to develop sleep apnea — a condition in which a person ceases to breathe for at least 10 seconds while sleeping — than the general population, according to a U.S. database study. These findings highlight the importance of screening for…

Excessive cortisol might have triggered an acute exacerbation of chronic hepatitis C — an inflammation of the liver caused by an infection with the hepatitis C virus — in a woman who also had Cushing’s syndrome, according to a recent report. The woman, who was scheduled to undergo an adrenalectomy…

Since 2008, Rare Disease Day — the last day of February — has brought together patients, caregivers, family members, friends, and advocates from around the world to raise awareness and improve equity for the more than 7,000 known rare diseases that affect more than 300 million people. In 2022, the…

When symptoms of Cushing’s syndrome return after adrenal cancer surgery, this may indicate that tumor cells have spread to other locations, a case report suggests. The report, “Functioning metastasis from adrenocortical carcinoma,” was published in the journal BMJ Case Reports. Malignant tumors in the adrenal glands —…

Hyperglycemia, or high concentrations of sugar in the blood, can be brought to normal levels, or considerably reduced, in almost 70% of people with both Cushing’s syndrome and hyperglycemia following curative surgery or radiation therapy, a study has found. The report highlighted the need for close monitoring and adjusting medications…

Xeris Biopharma’s newly approved therapy Recorlev (levoketoconazole) is now available to patients in the U.S. through the specialty pharmacy PANTHERx Rare, the company announced in a press release. The therapy is prescribed for adults with endogenous Cushing’s syndrome for whom surgery is not possible or not effective. “The commercial…

The use of large amounts of corticosteroids over a prolonged period of time — as a topical treatment for a 4-year-old girl who had previously undergone a large skin graft — triggered Cushing’s syndrome in the child, according to a recent case report. The girl was examined by clinicians after…