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Metoclopramide Can Mask Adrenal Insufficiency After Gland Removal in BMAH Patients, Case Report Suggests

Metoclopramide, a gastrointestinal medicine, can increase cortisol levels after unilateral adrenalectomy — the surgical removal of one adrenal gland — and conceal adrenal insufficiency in bilateral macronodular adrenal hyperplasia (BMAH) patients, a case report suggests. The study, “Retention of aberrant cortisol secretion in a patient with…

Nonprofit Group Works to Raise Rare Disease Awareness in India

With an estimated 1.37 billion inhabitants, India will likely surpass China in five years as the world’s most populous country. That also means it will have more rare-disease patients than any nation. It already has more than twice as many as the 28-member European Union. Harsha K. Rajasimha, a genomics…

Cortisol, ACTH Levels Identify Patients at Risk of Low Blood Potassium After Korlym Treatment, Study Says

Serum cortisol and adrenocorticotropic hormone (ACTH) levels may be useful in identifying Cushing’s syndrome patients at risk of experiencing low blood potassium levels while being treated with Korlym (mifepristone), Corcept Therapeutics’ researchers report. Their work, “Anticipating Hypokalemia in Patients With ACTH-Dependent Cushing Syndrome Treated…

High Cortisol Levels in Subclinical Cushing’s Syndrome Patients Linked to Risk of Metabolic Disease, Study Suggests

Elevated cortisol levels in people with subclinical Cushing’s syndrome appear to increase their likelihood of metabolic disease — a group of factors that raise the risk of heart disease — even though these patients don’t have the typical weight gain seen in overt Cushing’s syndrome, a study suggests. Results of the…

Changes in Salivary Cortisol May Help Diagnose Cushing’s Disease

Changes in salivary cortisol after desmopressin stimulation could be a supplementary tool in the diagnosis of Cushing’s disease, according to Brazilian researchers. Their study, “Desmopressin Stimulated Salivary Cortisol as a Supplementary Tool in the Diagnosis of Cushing’s Syndrome,” was presented at the recent Endocrine Society meeting (ENDO 2019) in New…