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Cushing’s syndrome can occur during pregnancy without obvious signs and symptoms specific to the condition, a new case report shows, suggesting the disease should be considered as a diagnosis in cases of high blood pressure during early pregnancy. The case report, “A case of subclinical Cushing’s…

A rare case of a woman with both endogenous and exogenous Cushing’s syndrome, demonstrating that both forms of the disease can coexist, is described in a case report. The case study, “A Curious Case of ‘Double Cushing Syndrome,’” was published in the journal AACE Clinical…

In addition to changes in volume of certain brain structures, people with Cushing’s syndrome also show widespread changes in the consistency of brain tissue, namely in white matter, which is made of nerve fibers or axons.  Importantly, such changes may correlate with disease symptoms. The study with those findings,…

The U.S. Food and Drug Administration (FDA), a vast government bureaucracy, employs about 17,500 people and had a budget of $5.7 billion in 2019. Yet even with its enormous resources, the FDA these days relies more and more on patients to…

The gleaming new Dutch headquarters of the European Medicines Agency (EMA), fronting Domenico Scarlattilaan in Amsterdam’s suburban Zuidas business district, finally opened for business last month — just over two years after the European Union decided to relocate the EMA to the Netherlands in the wake of Brexit.

Secretion of multiple hormones, high morning cortisol levels, higher tumor grade, and diabetes are all significantly associated with a worse prognosis for people with ectopic Cushing’s syndrome (ECS) caused by a neuroendocrine tumor, a new study found. The study, “Multiple hormone secretion may indicate…

Undiagnosed tumors on the adrenal glands — called adrenal incidentalomas, because they are found by chance — may be more prevalent than previously thought and also may be linked to an increased risk of type 2 diabetes, a new study has found. The study, “Adrenal incidentalomas…

More than 70% of patients have been enrolled in Strongbridge Biopharma’s Phase 3 LOGICS clinical trial assessing the safety and effectiveness of Recorlev (levoketoconazole) for treating endogenous Cushing’s syndrome, the company announced. Strongbridge anticipates announcing top-line results from the study before the end of this year and plans to…

Fat accumulation in muscles caused by Cushing’s syndrome leads to impaired muscle function and worse physical performance long after patients have achieved remission with normal cortisol levels, findings from a new study show. The study, “Thigh muscle fat infiltration is associated with impaired physical performance despite…

Ectopic ACTH-secreting pituitary adenomas (EAPAs), a rare cause of Cushing’s disease, are more commonly found in women, who also have a poorer prognosis than men with the same condition, a study suggests. Titled “Long-term follow-up for ectopic ACTH-secreting pituitary adenoma in a single tertiary medical…