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Researchers have identified several parameters that could help distinguish silent corticotroph adenomas — benign pituitary tumors that produce adrenocorticotropic hormone — from other nonfunctioning pituitary tumors. Because these tumors usually have a more aggressive clinical course, the findings may help determine the most appropriate management approach for patients before they undergo…

As President Trump signed the recently passed Right to Try legislation into law in a White House ceremony, Jordan McLinn of Indianapolis tried twice to embrace him. The third time, 9-year-old Jordan finally got the hug he wanted — as well as a kiss on the forehead. The video of…

A noninvasive and inexpensive technique could help improve the clinical assessment of bone damage in Cushing’s syndrome patients, a French study reports. The approach, called trabecular bone score, was better at detecting bone damage in these patients than the standard bone mineral density assessments. The study, “Assessment…

Finding treatments and potential cures for rare diseases is crucial, but so is the quality of patients’ lives — a rather nebulous term that means different things to different people. “Recently, there’s been much more of a focus on Quality of Life (QoL) issues, real-world evidence and patient-reported outcomes,” said…

Long-term treatment with Signifor LAR, a long-acting formulation of pasireotide, effectively reduced pituitary tumor volume and improved symptoms of Cushing’s disease, results from a Phase 3 extension trial show. These findings were discussed in the poster, “Long-Term Efficacy and Safety of Once-Monthly Pasireotide in Patients…

Radiation therapy targeting the entire sella — the compartment where the pituitary gland resides at the base of the brain — is effective at controlling Cushing’s disease and should be considered for patients with suspected invasive adenoma tumors, a new study shows. The study, “Technique of Whole-Sellar Stereotactic Radiosurgery for…

Cushing’s disease patients with macroadenomas — pituitary tumors larger than 10 mm — should undergo transsphenoidal pituitary surgery using the endoscopic technique, according to a new systematic review. The study, “Endoscopic vs. microscopic transsphenoidal surgery for Cushing’s disease: a systematic review and meta-analysis,” was published in…

Heart problems in Cushing’s syndrome patients may be partially reversed after tumor removal surgery, new research shows. For most patients in the study, the surgery also improved quality of life, mental and physical health, anxiety, and depression. However, 1 in 3 patients showed worse anxiety and depression scores, researchers…

Low levels of some hormone receptors in patients with subclinical Cushing’s syndrome and in those with a type of adrenal gland tumor called pheochromocytoma, all with abnormal hormone levels in their blood, were linked to weight gain and obesity, a risk factor for cardiovascular and other diseases. Increases in…

Etomidate — a steroid synthesis blocker — is an effective treatment for patients with severe Cushing’s syndrome who do not respond to ketoconazole, according to a new case report from Mexico. The report, “Etomidate in the control of severe Cushing’s syndrome by neuroendocrine carcinoma,” appeared…