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Patients with different subtypes of Cushing’s syndrome (CS) have distinct plasma steroid profiles. This could be used as a test for diagnosis and classification, a German study says. The study, “Plasma Steroid Metabolome for Diagnosis and Subtyping Patients with Cushing Syndrome,” appeared in the journal Clinical Chemistry. A…

Children with endogenous Cushing’s syndrome may have an abnormal white blood cell count, which relates to the severity of their disease and puts them at risk for infections. Their pattern of abnormalities are similar to that seen in adults with the disease, say researchers at the Eunice Kennedy Shriver…

Blood immune cells may contribute to metabolic and cardiovascular disease in patients with Cushing’s syndrome, suggest researchers at IDIBAPS in Barcelona, Spain. The research team showed that Cushing’s syndrome patients have increased numbers of certain immune cells in their blood, even though their increased cortisol levels are considered immunosuppressive. Moreover,…

Pregnant woman with hypertension and significant signs of hypercortisolism (high cortisol levels) may have Cushing’s disease, according to a new case report. The report, titled “A Case of Cushing’s Syndrome in Pregnancy,” was published in the Iranian Journal of Medical Sciences. While Cushing’s rarely occurs…

Scientists have developed a better method of diagnosing Cushing’s syndrome that measures cortisol levels in a patient’s saliva. The enhanced testing protocol improves upon a method originally developed for urine cortisol, a study shows. The study, “Clinical utility of an ultrasensitive late night salivary cortisol assay by tandem mass…

The surgical removal of two-thirds of the pituitary gland is associated with high initial remission rates and low operative morbidity in patients with suspected Cushing’s disease, when no tumor is found on the gland during surgical exploration. Cushing’s disease (CD) is caused by increased levels of glucocoticosteroids, such as…

Ectopic Cushing’s syndrome can be challenging to diagnose, especially when it comes identifying the problem source. But appropriate hormone management protocols, used in combination with advanced imaging methods, may help physicians identify ectopic ACTH-producing tumors. The findings in a case report of a young man with ectopic Cushing’s syndrome were…

All patients who undergo removal of one adrenal gland due to Cushing’s syndrome (CS) or adrenal incidentaloma (AI, adrenal tumors discovered incidentally) should receive a steroid substitutive therapy, a new study shows. The study, “Predictability of hypoadrenalism occurrence and duration after adrenalectomy for ACTH‐independent hypercortisolism,” was published…

Premenopausal women whose Cushing’s syndrome is in remission are at high risk of having a heart problem even if they don’t have a cardiovascular disease, a study shows. The research, “Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing Syndrome after remission,” was published in the…

Certain regions of the brain in patients with Cushing’s disease are associated with altered metabolism, indicating a mechanism of cognitive impairment, new study shows. The study, “Voxel-based comparison of brain glucose metabolism between patients with Cushing’s disease and healthy subjects,” was published in the journal…