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The glucocorticoid receptor antagonist CORT125134 is safe and has shown preliminary signs of efficacy in healthy volunteers participating in a Phase 1 trial, say researchers in England. Their study, “Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical…

A type of precision radiation therapy, called stereotactic radiosurgery (SRS), helped patients with Cushing’s disease (CD) control hypercortisolism. It may be a treatment alternative for those unable to undergo surgery or whose disease recurs after surgery, a retrospective analysis reported. The study, “Stereotactic Radiosurgery for Cushing’s Disease: Results of…

Late-night measures of cortisol levels in saliva may not be all that helpful in diagnosing Cushing’s syndrome, a group of physicians discovered upon learning that a difficult to diagnose patient had manipulated the samples. Although this behavior is extremely rare, the research team from the University of Calgary in…

Histone deacetylase inhibition (HDACi) improves hypertension and hyperglycemia in a rat model of Cushing’s syndrome (CS) by reducing activity of the glucocorticoid receptor, a new study shows. The study, “Histone Deacetylase Inhibition Ameliorates Hypertension and Hyperglycemia in a model of Cushing’s Syndrome,” was published in the…

A specific genetic mutation has been found in a patient with Cushing’s syndrome secondary to typical pulmonary carcinoid (TPC), a new Chinese study shows. The finding holds promise for progress in diagnosis and therapy. The study, “Cushing’s syndrome secondary to typical pulmonary carcinoid with mutation in BCOR…

Long-term follow-up and analysis of cortisol levels may help predict the recurrence of Cushing’s disease among patients who underwent surgery to remove their pituitary adenomas, a new study from India concludes. The study, “Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing’s disease,” appeared…

Patients with Cushing’s syndrome are nearly three times as likely to develop obstructive sleep apnea later in life than the general population, according to the findings of a large population study in Taiwan. The research, “Risk of obstructive sleep apnea among patients with Cushing’s syndrome: a nationwide…

Excess cortisol in cortisol-producing adenomas may be caused by a lack of chemical modifications in a gene involved in cortisol synthesis, new research found. The study shows that DNA methylation, a type of modification in the DNA whose function is to reduce protein expression, in the aldosterone synthase gene is significantly…

Patients with Cushing’s disease or other pituitary tumors who undergo radiotherapy after surgery have a higher chance of developing secondary brain tumors, a new study shows. Such patients should be followed for longer periods, and by multidisciplinary clinical teams, ensuring proper and prompt care. The study, “Secondary Intracranial Tumors…

Primary care physicians need to be aware of the typical signs of Cushing’s disease so they can initiate early screening, advocates a group of researchers from the University of Ghana. Their article, “Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know,” was…