Researchers at the Perelman School of Medicine at the University of Pennsylvania have successfully used a fluorescent dye to identify pituitary adenoma tissue during brain surgery. The study, “Folate receptor overexpression can be visualized in real time during pituitary adenoma endoscopic transsphenoidal surgery with near-infrared imaging,” was…
News
Fluorescent pigments accumulate in the non-cancerous adrenal gland tumors associated with Cushing syndrome, whether or not a person has a mutation associated with the disease, a study indicates. The build-up could be used a biomarker of Cushing disease some day, the researchers said. Scientists call the pigments lipofuscin granules. Granule accumulations…
Crinetics Pharmaceuticals has received two grants from the National Institutes of Health’s (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to develop nonpeptide, oral somatostatin agonists for congenital hyperinsulinemia and new therapies for Cushing’s disease. The two Small Business Innovation Research (SBIR) grants, totaling $2.4…
A retrospective analysis shows that nearly 30 percent of patients with Cushing’s disease (CD) are not able to control the levels of cortisol in their blood, despite multiple treatments. The study, “Biochemical Control During Long-term Follow-up of 230 Adult Patients with…
Strongbridge Biopharma has entered into an agreement for $50 million in credit and $3 million in equity investment with the healthcare-focused firm CRG to meet the demand for Keveyis (dichlorphenamide) and advance the development of its major therapeutic candidate Recorlev (levoketoconazole). Recorlev is an investigational cortisol synthesis inhibitor under development for the…
Researchers found that unlike tumors localized in the pituitary gland that increase production of the hormone underlying Cushing’s syndrome, no mutations in USP8 were detected in tumors that induce the disease but are localized outside of the gland. This condition is known as ectopic ACTH secretion syndrome (EAS), or ectopic Cushing’s…
The multicenter, international Phase 3 SONICS study testing the safety and effectiveness of Strongbridge Biopharma’s therapy candidate Recorlev (levoketoconazole) for endogenous Cushing’s syndrome has reached its goal of enlisting 90 participants, which completes the enrollment phase. Due to strong interest in the study, a…
The Cushing’s Support and Research Foundation (CSRF) is calling attention to three books of potential interest to Cushing’s Disease patients and to healthcare providers who treat the relatively rare endocrine disorder. In Cushing’s Disease, the adrenal glands release too much of the hormone cortisol into the body for long periods…
Ortho Clinical Diagnostics, a producer of in vitro diagnostics, has announced that Ortho’s Vitros Immunodiagnostic Products Insulin Reagent and Calibrators have received 510(k) clearance from the U.S. Food and Drug Administration (FDA). The insulin assay is part of a comprehensive diabetes…
A new Phase 3 clinical trial (NCT02697734) is actively recruiting Cushing’s disease patients in several countries to test the safety and effectiveness of the investigational therapy osilodrostat (LCI699). The 48-week, multicenter, randomized, double-blind, placebo-controlled study is sponsored by Novartis Pharmaceuticals. Estimated enrollment is 69 patients at 26 locations…
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