Andrea Lobo,  —

Long-term treatment with relacorilant led to a sustained decrease in blood pressure, blood sugar levels, and body weight in people with Cushing’s syndrome, new data from an extension study shows. The extension study (NCT03604198) is assessing relacorilant’s long-term safety and efficacy in 116 people with Cushing’s who completed…

Korlym (mifepristone) significantly reduced levels of hemoglobin A1c, a marker that reflects blood sugar levels over the previous months, in people with Cushing’s syndrome and difficult-to-control type 2 diabetes. That’s according to new data from a Phase 4 clinical trial, CATALYST (NCT05772169), which screened 1,057 patients with difficult-to-control…

Ectopic Cushing’s syndrome in a 10-year-old girl that was caused by a thymus tumor was effectively managed with ketoconazole and surgery to remove the thymus, according to a case report from the Czech Republic. “This case presents some unique challenges related to the diagnosis, management, and treatment of thymic…

People with Cushing’s syndrome are at a high risk of glaucoma — an eye condition in which the optic nerve that connects the eye and brain becomes damaged, potentially leading to vision loss — according to a new study that found the risk for Cushing’s patients is 74% greater than…

A 70-year-old woman in the U.S. with Cushing’s syndrome due to advanced adrenal gland cancer who was effectively managed with Isturisa (osilodrostat) was the subject of a report by researchers. After the woman developed adrenal insufficiency, which is when the adrenal glands become unable to produce sufficient amounts of…

Surgical removal of one cancerous adrenal gland resulted in disease remission after six months in nearly half of people with Cushing’s syndrome due to tumors in both adrenal glands — a condition known as primary bilateral macronodular adrenal hyperplasia, or PBMAH. That’s according to data from a study in China…

A 46-year-old man with Cushing’s disease in the U.S. lacked many of the typical symptoms due to impairments in the activity of an enzyme called 11 beta-hydroxysteroid dehydrogenase type 1 (HSD-1), according to a recent case report. HSD-1 is needed for cells to convert cortisone, an inactive form of…

Lack of patient-centered care, dismissing symptoms, and negative experiences related to changes in weight may delay recognizing and diagnosing Cushing’s syndrome by primary healthcare providers, a study that gathered the experiences and perceptions of seven women in Canada suggests. “Overall, the results of our study highlight the importance of…

The rare case of an 18-year-old woman with ectopic Cushing’s syndrome due to a neuroendocrine lung tumor — a rare tumor that may cause Cushing’s — was described by researchers at the Icahn School of Medicine at Mount Sinai in New York. The patient was successfully treated by surgically removing…

A higher volume of epicardial adipose tissue (EAT) — meaning more fat accumulated near the heart muscle and arteries that supply the heart — significantly increases the risk for early heart disease in people with Cushing’s syndrome. That’s according to a study from China that assessed risk factors for left…