Andrea Lobo,  —

A 71-year-old man with Cushing’s disease developed avascular necrosis in the hips and shoulders, a condition in which bone tissue dies due to lack of blood supply, a U.S. case study reports. His Cushing’s symptoms, including avascular necrosis in the hips, were successfully managed with surgery to remove the…

A young woman who developed Cushing’s syndrome three years after being diagnosed with a metastatic neuroendocrine tumor saw her cortisol levels decrease and Cushing’s-related symptoms ease after being treated with Isturisa (osilodrostat). The woman, 27, was started on hydrocortisone when here cortisol levels fell to lower than normal values,…

People with Cushing’s disease may have higher levels of cortisol and more severe symptoms than those with other forms of Cushing’s, according to a recent study in Turkey. “The severity of disease symptoms worsens with increasing cortisol levels,” researchers wrote. The study, “Metabolic, hormonal profiles and comorbidities in…

Partial adrenalectomy, or the removal of only a portion of the adrenal gland containing a tumor instead of the entire gland, using a minimally invasive procedure is safe and feasible in people with Cushing’s syndrome and other conditions, according to a study in Germany. The procedure, called posterior retroperitoneoscopic partial…

Older Cushing’s disease patients less frequently present classical symptoms of the disease, and have more coexistent conditions and larger tumors than those who develop the disease at a younger age. That’s according to a study that analyzed patients at several sites in the U.S. who underwent surgery to…

Long-term treatment with relacorilant led to a sustained decrease in blood pressure, blood sugar levels, and body weight in people with Cushing’s syndrome, new data from an extension study shows. The extension study (NCT03604198) is assessing relacorilant’s long-term safety and efficacy in 116 people with Cushing’s who completed…

Korlym (mifepristone) significantly reduced levels of hemoglobin A1c, a marker that reflects blood sugar levels over the previous months, in people with Cushing’s syndrome and difficult-to-control type 2 diabetes. That’s according to new data from a Phase 4 clinical trial, CATALYST (NCT05772169), which screened 1,057 patients with difficult-to-control…

Ectopic Cushing’s syndrome in a 10-year-old girl that was caused by a thymus tumor was effectively managed with ketoconazole and surgery to remove the thymus, according to a case report from the Czech Republic. “This case presents some unique challenges related to the diagnosis, management, and treatment of thymic…

People with Cushing’s syndrome are at a high risk of glaucoma — an eye condition in which the optic nerve that connects the eye and brain becomes damaged, potentially leading to vision loss — according to a new study that found the risk for Cushing’s patients is 74% greater than…

A 70-year-old woman in the U.S. with Cushing’s syndrome due to advanced adrenal gland cancer who was effectively managed with Isturisa (osilodrostat) was the subject of a report by researchers. After the woman developed adrenal insufficiency, which is when the adrenal glands become unable to produce sufficient amounts of…