Andrea Lobo,  —

A low-dose dexamethasone test, which is commonly used to diagnose Cushing’s syndrome, can effectively detect the rare condition in people with obesity, according to a new study. However, despite the test’s effectiveness, the proportion of patients who ultimately were diagnosed with Cushing’s was low, at 0.2%. Given that finding,…

In what researchers describe as an “exceedingly rare” case, adrenocorticotropic hormone (ACTH)-producing advanced adrenal gland cancer was determined to be the cause of Cushing’s syndrome in a 26-year-old woman in Portugal. Adrenocortical carcinoma is typically associated with ACTH-independent Cushing’s — forms of the syndrome in which excessive cortisol production is…

The rare case of a 14-year-old girl who experienced spontaneous remission of Cushing’s disease after pituitary tumor apoplexy has been reported by researchers in South America. Pituitary apoplexy, or PA, is a rare and potentially life-threatening condition caused by bleeding or infarction (cell death due to impaired blood flow)…

An invasive tumor in the thymus turned out to be the cause of a 31-year-old woman’s severe ectopic, adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, according to a case recently reported in Poland. As initial imaging scans failed to detect the thymus lesion, a tumor in the left adrenal gland was suspected…

Mutations in the USP8 gene are found in 35% of the pituitary corticotroph adenomas that cause Cushing’s disease, and more commonly affect women than men, a review study found. Thus, targeting the gene and epidermal growth factor receptor (EGFR) — whose levels are increased in patients with USP8 mutations…

A protein found in tissues that produce and release hormones may be a biomarker to help distinguish Cushing’s disease from adrenocorticotropic hormone (ACTH)-dependent ectopic Cushing’s. That’s according to a recent study in Japan that also reported that chromogranin A was higher in people with ACTH-dependent ectopic Cushing’s than those…

Among people with endogenous Cushing’s syndrome whose high blood pressure, or hypertension, dropped after five months on relacorilant, that response was maintained when the patients continued treatment for an additional period of three months. That’s according to new data from the randomized withdrawal phase of the Phase 3…

The prolonged use of an injectable medication containing an anti-inflammatory corticosteroid to treat abdominal pain led to the onset of Cushing’s syndrome in a 62-year-old woman, as described in a case reported by a team in Florida. The woman was being treated for pain associated with chronic inflammation in the…

A 44-year-old woman was found to have a hormone-producing tumor in her left adrenal gland, which produced and released both cortisol and testosterone, leading to the onset of Cushing’s syndrome. The high levels of testosterone produced and released by the tumor also caused her to develop virilization, a condition in…

About five months of treatment with relacorilant significantly reduced both high blood pressure and high blood sugar levels in people with endogenous Cushing’s syndrome, according to data from a Phase 3 trial. Relacorilant also was found to be generally safe and well tolerated, and to be able to significantly…