Andrea Lobo,  —

Mutations in the USP8 gene are found in 35% of the pituitary corticotroph adenomas that cause Cushing’s disease, and more commonly affect women than men, a review study found. Thus, targeting the gene and epidermal growth factor receptor (EGFR) — whose levels are increased in patients with USP8 mutations…

A protein found in tissues that produce and release hormones may be a biomarker to help distinguish Cushing’s disease from adrenocorticotropic hormone (ACTH)-dependent ectopic Cushing’s. That’s according to a recent study in Japan that also reported that chromogranin A was higher in people with ACTH-dependent ectopic Cushing’s than those…

Among people with endogenous Cushing’s syndrome whose high blood pressure, or hypertension, dropped after five months on relacorilant, that response was maintained when the patients continued treatment for an additional period of three months. That’s according to new data from the randomized withdrawal phase of the Phase 3…

The prolonged use of an injectable medication containing an anti-inflammatory corticosteroid to treat abdominal pain led to the onset of Cushing’s syndrome in a 62-year-old woman, as described in a case reported by a team in Florida. The woman was being treated for pain associated with chronic inflammation in the…

A 44-year-old woman was found to have a hormone-producing tumor in her left adrenal gland, which produced and released both cortisol and testosterone, leading to the onset of Cushing’s syndrome. The high levels of testosterone produced and released by the tumor also caused her to develop virilization, a condition in…

About five months of treatment with relacorilant significantly reduced both high blood pressure and high blood sugar levels in people with endogenous Cushing’s syndrome, according to data from a Phase 3 trial. Relacorilant also was found to be generally safe and well tolerated, and to be able to significantly…

A 66-year-old woman in South America was diagnosed with Cushing’s disease after being referred for a consultation with a specialist for obesity associated with pain and reduced mobility in the right knee, according to a new case study. Titled “From Knee Pain Consultation to Pituitary Surgery: The Challenge…

Changes in blood flow linked to obesity start in the early stages of Cushing’s disease, as evidenced by a significant decrease in the blood-pumping ability of the heart, a new study reported. While obese patients appeared to have normal heart function in standard echocardiographic examinations, a noninvasive method called…

A rare type of nasal tumor, called olfactory neuroblastoma, caused ectopic Cushing’s syndrome in a 47-year-old man, as described in a recent case report. Surgical treatment led to a reduction of the patient’s blood cortisol and adrenocorticotropic hormone (ACTH) levels, which were elevated as a result of the tumor. “This…

A timely diagnosis of Cushing’s syndrome during pregnancy, along with appropriate individualized treatment, is critical for minimizing complications for the mother and the child, according to a case series study that followed five pregnant women with Cushing’s caused by adrenal tumors at a hospital in China. “By implementing a multidisciplinary…