People with high cortisol levels have lower muscle mass and higher visceral fat deposits, putting them at a greater risk for cardiovascular disease, new research shows. High levels of cortisol can result from a variety of reasons, including Cushing’s disease and adrenal tumors. Most adrenal tumors are found to…
Interactions between the HIV antiretroviral therapy Norvir (ritonavir) and the pain relief medication Kenalog (triamcinolone) can lead to Cushing’s disease, according to a new report. The study, “Acute development of Cushing syndrome in an HIV-infected child on atazanavir/ritonavir based antiretroviral therapy,” appeared in the journal…
Bilateral inferior petrosal sinus sampling (IPSS) — a procedure that uses desmopressin to determine levels of ACTH hormone from veins that drain from the pituitary gland, is a sensitive way to diagnose patients with Cushing’s disease and find tumors, a Chinese study shows. The study,“Tumour Lateralization in…
Histone deacetylase inhibition (HDACi) improves hypertension and hyperglycemia in a rat model of Cushing’s syndrome (CS) by reducing activity of the glucocorticoid receptor, a new study shows. The study, “Histone Deacetylase Inhibition Ameliorates Hypertension and Hyperglycemia in a model of Cushing’s Syndrome,” was published in the…
Fluorescent pigments accumulate in the non-cancerous adrenal gland tumors associated with Cushing syndrome, whether or not a person has a mutation associated with the disease, a study indicates. The build-up could be used a biomarker of Cushing disease some day, the researchers said. Scientists call the pigments lipofuscin granules. Granule accumulations…
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