José Lopes, PhD, managing science editor —

New genetic mutations were found in a patient who exhibited atypical symptoms of Cushing’s syndrome, notably an abnormal protrusion of the eye, a case report shows. The research, “Extensive ARMC5 genetic variance in primary bilateral macronodular adrenal hyperplasia that started with exophthalmos: a case report,” was published…

The chemotherapy temozolomide partially improved a case of an aggressive pituitary tumor that caused symptoms of Cushing’s disease (CD), according to a new study in Poland. However, after tumor mass and cortisol levels were stabilized for a few months, the patient experienced rapid progression, suggesting that new methods for extending the…

The minimally invasive laparoscopic adrenalectomy (LA) is a safe and feasible procedure for larger adrenal tumors and metastasis, a new Italian study shows. While the findings suggest that the surgical application of laparoscopic adrenalectomy could be extended, surgeons should undergo a 30-procedure learning curve to improve surgical outcomes, researchers say.

The effects of obesity on the diagnosis of Cushing’s syndrome and strategies to alter the traditional approaches have been addressed in a new review study. The study, “Diagnosis and Differential Diagnosis of Cushing’s Syndrome,” appeared in The New England Journal of Medicine. The author…

An increase in glucose uptake by Cushing’s disease-associated pituitary tumors could improve their detection, new research shows. The study, “Corticotropin releasing hormone can selectively stimulate glucose uptake in corticotropinoma via glucose transporter 1,” appeared in the journal Molecular and Cellular Endocrinology. The study’s senior author was Dr.

A specific genetic mutation has been found in a patient with Cushing’s syndrome secondary to typical pulmonary carcinoid (TPC), a new Chinese study shows. The finding holds promise for progress in diagnosis and therapy. The study, “Cushing’s syndrome secondary to typical pulmonary carcinoid with mutation in BCOR…

A retrospective analysis shows that nearly 30 percent of patients with Cushing’s disease (CD) are not able to control the levels of cortisol in their blood, despite multiple treatments.  The study, “Biochemical Control During Long-term Follow-up of 230 Adult Patients with…