Persistent symptoms during corticosteroid tapering should prompt evaluation for an internal source of excess cortisol — usually from the adrenal glands above the kidneys — because exogenous steroid use can mask signs of Cushing’s syndrome that the body is producing on its own. That’s what happened in the case…
A woman with Cushing’s disease developed overlapping heart symptoms, a case researchers said highlights the need for early diagnosis and coordination between cardiologists and endocrinologists. The woman had cortisol-induced heart failure with preserved ejection fraction, meaning her heart pumped normally but was too stiff to fill properly. The heart…
The case of a young adolescent boy illustrates that doctors should carefully taper corticosteroids and regularly monitor hormones in children with autoimmune Vogt-Koyanagi-Harada disease (VKH) to prevent Cushing’s syndrome and other serious complications, according to a study. “Many pediatric patients with VKH and steroid-related complications are managed not only…
A woman in the U.K. with Cushing’s disease was successfully treated with Isturisa (osilodrostat), which helped lower her cortisol levels to normal and later allowed doctors to clearly identify her pituitary tumor on an MRI scan for surgical removal. If validated, “this approach could refine surgical planning and…
Care practices at a hospital in Taiwan align with those recommended by the Pituitary Society for patients with pituitary tumors, including those causing Cushing’s disease, a study found. The study found that practices at Taipei Veterans General Hospital fostered successful surgical interventions, a low risk of death, and a…
Prolonged use of high-dose corticosteroid nasal sprays can lead to Cushing’s syndrome in children, according to a case report on a young girl in Italy who was treated with intranasal betamethasone and mometasone furoate for nasal congestion. While it’s well known that Cushing’s syndrome can…
Ectopic Cushing’s syndrome can have different outcomes depending on tumor type, with about 8 in 10 people with lung tumors and 4 in 10 with pancreatic tumors remaining alive five years after diagnosis, according to a meta-analysis study by researchers in Sweden. Patients lived longer when the tumor could…
A test that uses the hormone-release stimulant desmopressin to trace the source of excess adrenocorticotropic hormone (ACTH) helped correctly diagnose Cushing’s disease in four children, but was less reliable in precisely locating the disease-causing tumor, according to a report from Iran. Desmopressin could be a “cost-effective alternative” to…
Measuring cortisol in a small sample of saliva collected late at night may work just as well as the 24-hour urine test — which involves collecting urine passed during the day and night — for checking whether Cushing’s disease is in remission after radiotherapy, a study by U.S. researchers…
Surgery for Cushing’s disease eases symptoms and improves heart health more effectively than medication, a new study by researchers at the University Hospital of Padova in Italy has found. However, some problems — specifically including obesity and high blood pressure — can still remain, especially if cortisol is not…
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