Prolonged use of high-dose corticosteroid nasal sprays can lead to Cushing’s syndrome in children, according to a case report on a young girl in Italy who was treated with intranasal betamethasone and mometasone furoate for nasal congestion. While it’s well known that Cushing’s syndrome can…
Ectopic Cushing’s syndrome can have different outcomes depending on tumor type, with about 8 in 10 people with lung tumors and 4 in 10 with pancreatic tumors remaining alive five years after diagnosis, according to a meta-analysis study by researchers in Sweden. Patients lived longer when the tumor could…
A test that uses the hormone-release stimulant desmopressin to trace the source of excess adrenocorticotropic hormone (ACTH) helped correctly diagnose Cushing’s disease in four children, but was less reliable in precisely locating the disease-causing tumor, according to a report from Iran. Desmopressin could be a “cost-effective alternative” to…
Measuring cortisol in a small sample of saliva collected late at night may work just as well as the 24-hour urine test — which involves collecting urine passed during the day and night — for checking whether Cushing’s disease is in remission after radiotherapy, a study by U.S. researchers…
Surgery for Cushing’s disease eases symptoms and improves heart health more effectively than medication, a new study by researchers at the University Hospital of Padova in Italy has found. However, some problems — specifically including obesity and high blood pressure — can still remain, especially if cortisol is not…
Endoscopic transsphenoidal surgery, which allows a surgeon to gain access to the brain through the nose to remove a pituitary tumor causing Cushing’s disease, was found to be safe and effective for bringing about remission in children, with few complications. While this surgery is usually done in adults with…
One person out of five with Cushing’s syndrome in Israel has higher than normal numbers of white blood cells that drop within two years after surgery, but may still remain higher than the general population, a study finds. Patients with Cushing’s disease, a specific type of Cushing’s syndrome…
People with Cushing’s syndrome, including those with Cushing’s disease, are at a higher risk of developing cataracts, causing blurry vision, than the general population, a study from Israel finds. Cataracts, which occur when the eye’s lens becomes cloudy, also developed nearly three years earlier than in the general population,…
Patients being treated with Isturisa (osilodrostat) for Cushing’s disease see better long-term clinical outcomes when both late-night salivary cortisol and mean urinary free cortisol returned to normal levels, instead of just one or neither of those measures. Drawing on data from two Phase 3 clinical studies, LINC-3…
All patients who completed a Phase 2 clinical trial of clofutriben, an oral small molecule that Sparrow Pharmaceuticals is developing for endogenous Cushing’s syndrome, chose to continue on the experimental treatment as part of a planned open-label extension. Overall, the results of the trial, dubbed RESCUE, showed promise, Sparrow…
Get regular updates to your inbox.