Margarida Maia, PhD,  science writer—

Treatment with Isturisa (osilodrostat) for 1.5 years or longer kept urine cortisol levels close to normal in patients with Cushing’s disease, and this translated into fewer symptoms with no new side effects, a study has found. The findings come from an extension of LINC-3 (NCT02180217), a Phase…

Roughly half of people worldwide with Cushing’s syndrome see their diagnosis delayed by more than two years despite showing symptoms of the disease, according to a new international survey. Researchers found that this delay perhaps occurs because doctors dismiss some of the hormonal disorder’s initial symptoms — which…

A man with a known history of human immunodeficiency virus (HIV) infection and asthma developed Cushing’s syndrome after taking Tybost (cobicistat) together with fluticasone, according to a report from Spain. Tybost is a antiretroviral medicine booster, while fluticasone is a corticosteroid. The condition occurred because Tybost slows down how fast…

A man developed Cushing’s syndrome that was caused by a tumor in his prostate gland, according to a report from Singapore. He did not present the usual symptoms of Cushing’s, but instead appeared to have a severe excess of cortisol, the body’s main stress hormone. His symptoms included lower-than-normal…

People with an excess of cortisol due to a benign tumor in the adrenal glands, known as an adrenal adenoma, can be more prone to bone loss even if the excess is mild, according to a Japanese study. Bone loss was more common in women and patients with a low…

Adult stem cells derived from the belly skin of healthy people behaved in a similar way to fat cells when challenged to grow in an environment mimicking Cushing’s syndrome, a study found. According to the study’s authors, these cells “could represent a reliable model to track the mechanisms” involved in…

There are sets of microRNAs that may be used as markers for inherited or newly arising primary macronodular adrenal hyperplasia (PMAH), a rare cause of Cushing’s syndrome, a small study found. According to researchers, these microRNAs — short RNA molecules that help control the activity of certain genes — also…

Excessive cortisol might have triggered an acute exacerbation of chronic hepatitis C — an inflammation of the liver caused by an infection with the hepatitis C virus — in a woman who also had Cushing’s syndrome, according to a recent report. The woman, who was scheduled to undergo an adrenalectomy…

The case of an elderly woman who may have developed Cushing’s syndrome due to a hormone-producing lump in her lungs highlights the need for a timely and “multidisciplinary approach in [the] diagnosis and management” of hypercortisolism disorders, according to a new report. This patient’s signs and symptoms progressed…

Cushing’s syndrome triggered by different causes can have similar effects on a person’s metabolism, or the set of chemical changes that take place in the body, a study suggests. The study, “Metabolic profile differences in ACTH-dependent and ACTH-independent Cushing syndrome,” was published in the journal Chronic Diseases…