Marisa Wexler, MS,  senior science writer—

In rare cases, Cushing’s syndrome can be caused by tumors that are simultaneously producing two signaling molecules called adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH). Diagnosing Cushing’s in these cases can be complex, leading to delays in treatment and worse outcomes for patients, according to a new report. “Studies…

Differences in the levels of hormones made by the adrenal glands, which sit atop the kidneys, may explain why bone density is less affected in women with Cushing’s disease than in female patients with other forms of Cushing’s syndrome, a new study from researchers in China reports. Their results…

Long-term treatment with Isturisa (osilodrostat) may help lower blood pressure, and blood sugar, levels in people with Cushing’s disease who have high blood pressure, also known as hypertension, or diabetes, according to a new analysis. Use of the approved medication for up to 1.4 years helped to ease…

People with Cushing’s syndrome are at an increased risk of experiencing dangerous blood clotting events in the years following diagnosis, according to a recent study. These data underscore “the critical need for heightened vigilance and targeted management strategies in this high-risk population,” researchers wrote. The study, “Can…

A rare and aggressive form of thyroid cancer caused Cushing’s syndrome in a man in his 30s, according to a case report. “This case underscores the complexity of diagnosing and managing ectopic Cushing’s syndrome, particularly when it is secondary to a rare malignancy,” researchers wrote. The case report, “…

Corcept Therapeutics has asked the U.S. Food and Drug Administration (FDA) to approve relacorilant for people with endogenous Cushing’s syndrome. “Relacorilant’s combination of efficacy and safety give it the potential to become the standard of care for the medical treatment of patients with hypercortisolism,” Joseph Belanoff, MD, CEO…

People with Cushing’s disease frequently experience cognitive and psychiatric complications, often persisting after surgery to remove the disease-driving tumor, a review study noted. That could be because high cortisol levels during active phases of Cushing’s disease can cause physical changes in brain structure that persist after cortisol levels are…

Changes in gut bacteria may underlie the development of mental health problems in people with Cushing’s disease, a study found. The study, “The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice,” was published in Microbiome. Cushing’s disease is characterized by…

People with Cushing’s disease are at an increased risk of complications, particularly psychiatric disorders requiring hospitalization, even after the disease-causing tumor has been surgically removed, a study indicates. Its findings “support the need for comprehensive clinical evaluation and tailored interventions for [Cushing’s disease] patients, even post-surgery,” the researchers wrote.

Analyzing the gene activity profile of blood cells may help detect Cushing’s syndrome and could be useful in assessing its severity, a recent study reports. The study, “Whole blood transcriptomic signature of Cushing’s syndrome,” was published in the European Journal of Endocrinology. Cushing’s syndrome is an umbrella…