Marisa Wexler, MS,  senior science writer—

Isturisa (osilodrostat) is now available in Germany to treat adults with endogenous Cushing’s syndrome. The announcement by Recordati Rare Diseases, which acquired rights to Isturisa from its original developer Novartis, follows the medication recently becoming available in the U.S. and in France. Isturisa…

A newly developed smart contact lens might be used to measure levels of the hormone cortisol in a person’s tears, which could be helpful in disorders such as Cushing’s disease. The new device was described in Science Advances, in the study, “Smart, soft contact lens for…

Cushing’s syndrome treatment Isturisa (osilodrostat) now is commercially available in France. The announcement from Recordati Rare Diseases comes soon after the medication became fully available for sale and distribution to adults in the U.S. The company stated that the medication will be made available elsewhere in the European Union…

Making incisions through the back of the body, rather than the front, can lessen bleeding and shorten operation time during surgery to remove the adrenal glands, a new study suggests. The study, “Comparison of synchronous bilateral transperitoneal and posterior retroperitoneal laparoscopic adrenalectomy: results of a multicenter study,”…

Cushing’s syndrome can occur during pregnancy without obvious signs and symptoms specific to the condition, a new case report shows, suggesting the disease should be considered as a diagnosis in cases of high blood pressure during early pregnancy. The case report, “A case of subclinical Cushing’s…

Undiagnosed tumors on the adrenal glands — called adrenal incidentalomas, because they are found by chance — may be more prevalent than previously thought and also may be linked to an increased risk of type 2 diabetes, a new study has found. The study, “Adrenal incidentalomas…

Ectopic ACTH-secreting pituitary adenomas (EAPAs), a rare cause of Cushing’s disease, are more commonly found in women, who also have a poorer prognosis than men with the same condition, a study suggests. Titled “Long-term follow-up for ectopic ACTH-secreting pituitary adenoma in a single tertiary medical…

A diagnostic technique called bilateral inferior petrosal sinus sampling (BIPSS), which measures the levels of the adrenocorticotropic hormone (ACTH) produced by the pituitary gland, should only be used to diagnose cyclic Cushing’s syndrome patients during periods of cortisol excess, a case report shows. When it…

Cushing’s disease patients who are treated with cabergoline while undergoing conventional fractionated radiotherapy have a higher risk of disease recurrence after initial remission, a small study has found. The study, “Cabergoline may act as a radioprotective agent in Cushing’s disease,” was published in Clinical Endocrinology. Radiation…

Targeting the USP8 protein, which is frequently mutated in Cushing’s disease patients, lowered the levels of adrenocorticotropic hormone, inhibited cell proliferation, and caused cell death in a mouse cell model of the disease, a study found. As a result, USP8 may be a promising target for therapies…