Corcept Therapeutics has asked the U.S. Food and Drug Administration (FDA) to approve relacorilant for people with endogenous Cushing’s syndrome. “Relacorilant’s combination of efficacy and safety give it the potential to become the standard of care for the medical treatment of patients with hypercortisolism,” Joseph Belanoff, MD, CEO…
People with Cushing’s disease frequently experience cognitive and psychiatric complications, often persisting after surgery to remove the disease-driving tumor, a review study noted. That could be because high cortisol levels during active phases of Cushing’s disease can cause physical changes in brain structure that persist after cortisol levels are…
Changes in gut bacteria may underlie the development of mental health problems in people with Cushing’s disease, a study found. The study, “The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice,” was published in Microbiome. Cushing’s disease is characterized by…
People with Cushing’s disease are at an increased risk of complications, particularly psychiatric disorders requiring hospitalization, even after the disease-causing tumor has been surgically removed, a study indicates. Its findings “support the need for comprehensive clinical evaluation and tailored interventions for [Cushing’s disease] patients, even post-surgery,” the researchers wrote.
Analyzing the gene activity profile of blood cells may help detect Cushing’s syndrome and could be useful in assessing its severity, a recent study reports. The study, “Whole blood transcriptomic signature of Cushing’s syndrome,” was published in the European Journal of Endocrinology. Cushing’s syndrome is an umbrella…
Daily meditation with the help of headband that tracks brain activity and serves as a personal meditation coach may help people with Cushing’s syndrome have less pain and a better experience while recovering from surgery. That’s according to new research presented at the Endocrine Society Annual Meeting (ENDO 2024) in…
People with Cushing’s syndrome have an increased risk of venous thromboembolism (VTE), that is, dangerous blood clots that obstruct the normal flow of blood through veins, but most treatment centers don’t have standard procedures for reducing VTE risk in Cushing’s patients, a study indicates. “A specific thromboprophylaxis protocol for patients…
Cushing’s Awareness Day is April 8, and the Cushing’s community is gearing up with events and fundraising efforts to spread awareness and raise money to combat the disorder. In celebration of this year’s Awareness Day, Xeris Pharmaceuticals, which markets Cushing’s treatment Recorlev (levoketoconazole), is teaming up with the…
A Phase 3 trial testing the oral medication relacorilant in people with Cushing’s syndrome caused by adrenal adenoma, a type of adrenal gland tumor, or adrenal hyperplasia, a condition in which the adrenal glands become enlarged, has finished enrolling participants. Relacorilant’s developer, Corcept Therapeutics, said 137 participants have…
An interaction between an anti-inflammatory steroid and an anti-fungal medication led to the onset of Cushing’s syndrome and reduced adrenal gland function in a man being treated for complications from a bone marrow transplant. A case report on the 67-year-old man’s symptoms highlights possibly serious consequences from these medicines’…
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