Researchers have confirmed a relationship between increasing doses of Isturisa (osilodrostat) and decreasing levels of cortisol in the bloodstream of adults with Cushing’s disease and other forms of Cushing’s syndrome, according to a study report. Within one hour of Isturisa intake, patients’ blood cortisol reached the lowest levels,…
In recent years, fewer people are presenting with classic features of Cushing’s disease, such as moon face and purple stretch marks, according to a three-decade analysis of disease management. Patients diagnosed more recently are also older, and they have lower levels of cortisol and smaller pituitary tumors than those…
Transsphenoidal surgery, a minimally invasive procedure to remove pituitary tumors through the nose, achieved long-term remission in nearly all children with Cushing’s disease who participated in a single-center study in China. “While recurrence occurred in a minority of patients, primarily those with [small tumors], durable disease control is attainable for…
Limiting the number of measurements in the low-dose overnight dexamethasone suppression test (oDST), which is commonly used to diagnose Cushing’s syndrome, does not affect the test’s performance, a study showed. A new protocol, called Reflex, performs additional tests only among people whose initial tests suggest the presence of Cushing’s.
Long-term use of topical corticosteroids for a genetic skin condition caused Cushing’s syndrome and adrenal insufficiency — low hormone production from the adrenal glands — in a 50-year-old woman, according to a case report. “This case highlights the risk of systemic complications from chronic topical corticosteroid use,” the researchers wrote.
A combination of two noninvasive tests — the dexamethasone suppression test and high-resolution MRI scans — was found to correctly distinguish between Cushing’s disease and ectopic Cushing’s syndrome in patients, according to a new study. The accuracy seen in combining these tests was comparable to that of bilateral inferior…
Korlym (mifepristone) lowered the levels of hemoglobin A1c (HbA1c), which reflects the average amount of blood sugar over the past three months, in people with Cushing’s syndrome and treatment-resistant type 2 diabetes. That’s according to newly published data from the now-complete Phase 4 CATALYST (NCT05772169) clinical trial, which…
Surgery to remove pituitary tumors, the first-line treatment for Cushing’s disease, can increase the risk of venous thromboembolism (VTE), or blood clot formation in veins, especially within a week of the procedure, according to a new study. Identified risk factors for post-surgical VTE include older age, high blood pressure,…
Surgeons used ultrasound to successfully remove a pituitary tumor that was undetectable by MRI to cure a 55-year-old woman of Cushing’s disease, a case study reported. The case “suggests the potential utility of ultrasound in MRI-negative Cushing’s disease,” the researchers wrote. “It raises the possibility that even small pituitary…
Most people with Cushing’s syndrome see their adrenal function recover after first-line surgery to remove disease-causing tumors, even though it may take several months or years, according to a study that also showed a younger age at diagnosis was linked to faster adrenal recovery. “The recovery rate of adrenal function…
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