News

Relacorilant, an investigational therapy developed by Corcept Therapeutics, may effectively manage the effects of excess cortisol in patients with Cushing’s syndrome, interim data from an ongoing Phase 2 trial show. In particular, the treatment significantly improved sugar tolerance and the levels of osteocalcin, a bone growth biomarker  commonly suppressed by…

Millendo Therapeutics‘ experimental small molecule ATR-101 shows promise as a treatment for Cushing’s disease in dogs, suggesting its potential in humans with the syndrome, according to a new study. It also suggests that dogs with naturally occurring Cushing’s could be used as a model for human disease. The disease is…

“Functional” adrenal incidentalomas — abnormal masses found by chance in the adrenal glands that are capable of secreting cortisol and causing Cushing’s syndrome — may occur more frequently than previously estimated, a small Japanese study suggests. These findings suggest that adrenal incidentalomas should be carefully examined, the researchers said.

While adrenocortical carcinoma — a malignant tumor of the adrenal gland — appears only rarely in children, the tumor may cause secondary Cushing’s syndrome in these patients, a new case report shows. Early diagnosis of the causes of Cushing’s syndrome could improve the prognosis of these children, researchers say. The…

In rare cases, Cushing’s syndrome may be caused by cortisol-secreting masses in both adrenal glands, a case report shows. The study with that finding, “ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures” was published in BMC Endocrine Disorders. Cushing’s syndrome…

At least 800 people representing some 45 countries are soon expected to gather in Austria’s capital city, Vienna, for ECRD 2018, the 9th European Conference on Rare Diseases and Orphan Products. The May 10-12 meeting is sponsored by Eurordis, the Paris-based group that defines itself as a “patient-driven alliance”…

Obesity can be triggered by detrimental changes to the normal daily rhythms of hormone production, leading to an increased production of fat cells, research in mice shows. These findings help to explain why conditions that disturb hormone levels, such as Cushing’s disease…

Ketoconazole is a safe treatment for Cushing’s syndrome patients, but close monitoring of liver function markers should be done for up to six months, a French study shows. The study, “Hepatic safety of ketoconazole in Cushing’s syndrome: results of a compassionate use program in France,” appeared in the…

High lipid levels in the blood may lead to elevated blood pressure in patients with Cushing’s disease, a Chinese study shows. The study, “Evaluation of Lipid Profile and Its Relationship with Blood Pressure in Patients with Cushing’s Disease,” appeared in the journal Endocrine Connections. Patients with Cushing’s…

After adjusting for remission rates, patients with Cushing’s syndrome were found to have similar health-related quality of life (HRQoL) scores at long-term follow-up, regardless of whether the disease originated in the pituitary or adrenal gland, according to a recent study. The study, “Worse Health‐Related Quality of Life at…