News

Strongbridge Biopharma is expecting a second patent on its Cushing’s syndrome therapy Recorlev (levoketoconazole). The signal it received was the U.S. Patent and Trademark Office completing a review of its new patent application for the cortisol synthesis inhibitor. The second patent, which would expire Jan. 10, 2026, would cover other conditions in…

The level of decline in blood cortisol levels in the immediate period after transsphenoidal surgery for Cushing’s disease may help predict which patients will achieve long-term disease remission. The study, “Earlier post-operative hypocortisolemia may predict durable remission from Cushing’s Disease” was published in the European Journal…

Therapies known as histone deacetylase inhibitors reduced fatty liver disease in a rat model of Cushing’s syndrome, a study reports. (HDACi) was found to reduce hepatic steatosis – also known as fatty liver disease – in a rat model of Cushing’s syndrome, according to a new study. Researchers’ article, “Histone…

Lower muscle mass and higher visceral fat are correlated to higher cortisol levels, and can be used as reliable biomarkers to assess disease severity in patients with adrenal adenomas, a new study shows. The study, “Impact of hypercortisolism on skeletal muscle mass and adipose tissue mass in…

Hydrocortisone and prednisone have comparable safety and effectiveness when used as glucocorticoid replacement therapy in patients with adrenal adenoma or Cushing’s disease who underwent adrenalectomy, a new study shows. The study, “Comparison of hydrocortisone and prednisone in the glucocorticoid replacement therapy post-adrenalectomy of Cushing’s Syndrome,” was published in the journal…

Researchers studying two Chinese families affected by a rare form of Cushing’s syndrome found that two mutations affecting the ARMC5 gene — which had not been described to date — caused the disorder. Their study, “Whole-genome sequencing revealed armadillo repeat containing 5 (ARMC5) mutation in a Chinese family with…

Measuring blood serum cortisol levels several times a day after pituitary tumor surgery for Cushing’s disease can help doctors predict whether the operation eliminated the disorder, a study reports. The hormone measurements are also valuable for determining if a patient needs a second surgery, which improves the chance that the…

Removing asymptomatic benign tumors that grow in the adrenal gland is safe and effectively reduces health-risks associated with these tumors in elderly patients, a case report suggests. The report, “Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient” was published at Internal Medicine, the…

Patients with different subtypes of Cushing’s syndrome (CS) have distinct plasma steroid profiles. This could be used as a test for diagnosis and classification, a German study says. The study, “Plasma Steroid Metabolome for Diagnosis and Subtyping Patients with Cushing Syndrome,” appeared in the journal Clinical Chemistry. A…

Children with endogenous Cushing’s syndrome may have an abnormal white blood cell count, which relates to the severity of their disease and puts them at risk for infections. Their pattern of abnormalities are similar to that seen in adults with the disease, say researchers at the Eunice Kennedy Shriver…