Posts by: Alice Melao

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Novartis is launching a Phase 2 trial to assess the safety and efficacy of its investigational therapy osilodrostat — an inhibitor of cortisol synthesis — in children with Cushing’s disease. ... Read more

March 12, 2019

Arterial Blood Clots May Be First Sign of Cushing’s Syndrome, Case Report Shows

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In rare cases, the appearance of blood clots in arteries may be the first symptom of Cushing’s syndrome, a case report shows. That finding, “Arterial thrombosis as primary presentation ... Read more

March 7, 2019

Targeted Radiosurgery Suitable for Youngsters with Cushing’s Disease and Acromegaly, Study Shows

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Stereotactic radiosurgery — a targeted form of radiation therapy — can effectively reduce hormone levels and control tumor progression in children and adolescents with hormone-secreting pituitary adenomas, particularly those ... Read more

March 5, 2019

Cushing’s Syndrome Patients at High Risk of Bone Problems Regardless of Vitamin D Levels, Study Shows

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Cushing’s syndrome patients have a higher risk of fractures due to reduced bone mineral density and osteoporosis, but these issues are not associated with vitamin D or parathyroid hormone ... Read more

February 26, 2019

Long-term ACTH Exposure Causes Recurrence in Surgically Managed Cushing’s Patient

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Long-term exposure to high levels of the adrenocorticotropic hormone (ACTH) may lead to a recurrence of Cushing’s disease even after surgical treatment, according to a case report. Detailed guidelines ... Read more

January 8, 2019

Corcept to Receive US Patent on Use of Korlym Plus CYP3A Inhibitors to Treat Cushing’s

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Corcept Therapeutics has received notice that it will be issued a new patent in the U.S. covering the use of Korlym (mifepristone), in combination with strong CYP3A inhibitors, to treat ... Read more

November 20, 2018

Mutations in Two Genes, USP48 and BRAF, Linked to Cushing’s Disease in Study

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Mutations in USP48 and BRAF genes contribute to the overproduction of adrenocorticotropin (ACTH) hormone by the pituitary gland and consequent development of Cushing’s disease, a study shows, linking these ... Read more

June 22, 2018

Tumors in Cushing’s Patients Have Distinct Genetic Profiles, Study Shows

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A study examining the genes expressed in pituitary tumors of Cushing’s disease patients found that these tumors may be grouped into three distinct subsets. The finding suggests that different ... Read more

June 21, 2018

Adrenal Crisis Not a Major Cause of Death in Cushing’s Patients with Adrenal Insufficiency

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Cushing’s syndrome patients who have adrenal insufficiency have increased risk of death due to disease-related complications, rather than adrenal crisis or adverse occurrences, an observational study suggests. The study, ... Read more

June 15, 2018

Cushing’s Patients at Risk of Life-threatening Pulmonary Fungal Infection, Case Studies Suggest

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Cushing’s disease patients who exhibit nodules or masses in their lungs should be thoroughly investigated to exclude fungal infection with Cryptococcus neoformans, a study from China suggests. While rare, the infection ... Read more

Posts by: Alice Melao

Alice Melao

Phase 2 Trial to Assess Osilodrostat as Treatment for Children with Cushing’s Disease

Arterial Blood Clots May Be First Sign of Cushing’s Syndrome, Case Report Shows

Targeted Radiosurgery Suitable for Youngsters with Cushing’s Disease and Acromegaly, Study Shows

Cushing’s Syndrome Patients at High Risk of Bone Problems Regardless of Vitamin D Levels, Study Shows

Long-term ACTH Exposure Causes Recurrence in Surgically Managed Cushing’s Patient

Corcept to Receive US Patent on Use of Korlym Plus CYP3A Inhibitors to Treat Cushing’s

Mutations in Two Genes, USP48 and BRAF, Linked to Cushing’s Disease in Study

Tumors in Cushing’s Patients Have Distinct Genetic Profiles, Study Shows

Adrenal Crisis Not a Major Cause of Death in Cushing’s Patients with Adrenal Insufficiency

Cushing’s Patients at Risk of Life-threatening Pulmonary Fungal Infection, Case Studies Suggest

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