Posts by: Alice Melao

Alice Melao

October 31, 2019

Doctors Should Suspect Cushing’s Syndrome in Cases of Treatment-resistant Depression, Report Suggests

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Doctors should suspect Cushing’s syndrome in cases of depression that do not respond to medication or other interventions, avoiding misdiagnosis and unnecessary treatment, a case report suggests. While reducing cortisol ... Read more

October 29, 2019

Long-term Topical Corticosteroid Use can Cause Secondary Cushing’s Syndrome in Adults, Case Report Shows

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Long-term use of topical corticosteroids to treat skin problems can trigger secondary Cushing’s syndrome in adults, with a severe impact on bone health, a case report shows. The study, ... Read more

August 13, 2019September 9, 2019

Corticosteroid-based Creams Can Cause Secondary Cushing’s Syndrome in Infants, Case Report Shows

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Using topical creams with high corticosteroid concentrations to manage skin rash in infants can lead to the development of drug-related secondary Cushing’s syndrome, a case report shows. Therefore, the ... Read more

July 23, 2019

Recordati Acquires Global Rights Over Signifor and Osilodrostat

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Recordati has acquired worldwide rights over Novartis‘ investigational therapy osilodrostat (LCI699), being developed for the treatment of endogenous Cushing’s disease. The agreement also covers Signifor (pasireotide), an approved treatment for ... Read more

July 16, 2019

Pituitary Tissue Analysis During Surgery Improves Cushing’s Diagnosis, Study Says

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Pituitary gland tissue analysis during surgery can help confirm a Cushing’s disease diagnosis and define the best strategy to treat patients with small pituitary tumors, according to a study. ... Read more

June 27, 2019

Researchers Report Rare Case of Cushing’s Caused by Bilateral Adrenal Tumors

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Cases of adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome are often caused by unilateral tumors in the adrenal glands, but Indian researchers have now reported a rare case where the condition ... Read more

April 2, 2019

Phase 2 Trial to Assess Osilodrostat as Treatment for Children with Cushing’s Disease

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Novartis is launching a Phase 2 trial to assess the safety and efficacy of its investigational therapy osilodrostat — an inhibitor of cortisol synthesis — in children with Cushing’s disease. ... Read more

March 12, 2019

Arterial Blood Clots May Be First Sign of Cushing’s Syndrome, Case Report Shows

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In rare cases, the appearance of blood clots in arteries may be the first symptom of Cushing’s syndrome, a case report shows. That finding, “Arterial thrombosis as primary presentation ... Read more

March 7, 2019

Targeted Radiosurgery Suitable for Youngsters with Cushing’s Disease and Acromegaly, Study Shows

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Stereotactic radiosurgery — a targeted form of radiation therapy — can effectively reduce hormone levels and control tumor progression in children and adolescents with hormone-secreting pituitary adenomas, particularly those ... Read more

March 5, 2019

Cushing’s Syndrome Patients at High Risk of Bone Problems Regardless of Vitamin D Levels, Study Shows

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Cushing’s syndrome patients have a higher risk of fractures due to reduced bone mineral density and osteoporosis, but these issues are not associated with vitamin D or parathyroid hormone ... Read more

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