Posts by: Alice Melao

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Corcept Therapeutics has received notice that it will be issued a new patent in the U.S. covering the use of Korlym (mifepristone), in combination with strong CYP3A inhibitors, to treat ... Read more

November 20, 2018

Mutations in Two Genes, USP48 and BRAF, Linked to Cushing’s Disease in Study

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Mutations in USP48 and BRAF genes contribute to the overproduction of adrenocorticotropin (ACTH) hormone by the pituitary gland and consequent development of Cushing’s disease, a study shows, linking these ... Read more

June 22, 2018

Tumors in Cushing’s Patients Have Distinct Genetic Profiles, Study Shows

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A study examining the genes expressed in pituitary tumors of Cushing’s disease patients found that these tumors may be grouped into three distinct subsets. The finding suggests that different ... Read more

June 21, 2018

Adrenal Crisis Not a Major Cause of Death in Cushing’s Patients with Adrenal Insufficiency

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Cushing’s syndrome patients who have adrenal insufficiency have increased risk of death due to disease-related complications, rather than adrenal crisis or adverse occurrences, an observational study suggests. The study, ... Read more

June 15, 2018

Cushing’s Patients at Risk of Life-threatening Pulmonary Fungal Infection, Case Studies Suggest

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Cushing’s disease patients who exhibit nodules or masses in their lungs should be thoroughly investigated to exclude fungal infection with Cryptococcus neoformans, a study from China suggests. While rare, the infection ... Read more

June 7, 2018

Children with Pituitary Adenomas Have Similar Outcomes as Adult Patients, Study Shows

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Children with pituitary adenomas have similar responses to surgery and long-term outcomes as adult patients with the same type of tumors, new research shows. The only exception are growth ... Read more

June 5, 2018June 5, 2018

Study Describes Clinical Features that May Help Distinguish Silent Corticotroph Adenomas

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Researchers have identified several parameters that could help distinguish silent corticotroph adenomas — benign pituitary tumors that produce adrenocorticotropic hormone — from other nonfunctioning pituitary tumors. Because these tumors usually ... Read more

May 29, 2018

Signifor LAR Shows Long-term Benefits for Cushing’s Disease Patients in Phase 3 Extension Trial

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Long-term treatment with Signifor LAR, a long-acting formulation of pasireotide, effectively reduced pituitary tumor volume and improved symptoms of Cushing’s disease, results from a Phase 3 extension trial show. ... Read more

May 15, 2018May 15, 2018

Study Describes 6 Common Surgical Failures in Cushing’s Disease Treatment

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To help improve the effectiveness of surgical treatment of Cushing’s disease, researchers conducted a study to determine common failures. They classified these failures into six different categories. Results were ... Read more

May 11, 2018

Relacorilant Effectively Manages Cortisol Effects in Cushing’s Patients, Interim Phase 2 Data Show

News

Relacorilant, an investigational therapy developed by Corcept Therapeutics, may effectively manage the effects of excess cortisol in patients with Cushing’s syndrome, interim data from an ongoing Phase 2 trial show. ... Read more

Posts by: Alice Melao

Alice Melao

Corcept to Receive US Patent on Use of Korlym Plus CYP3A Inhibitors to Treat Cushing’s

Mutations in Two Genes, USP48 and BRAF, Linked to Cushing’s Disease in Study

Tumors in Cushing’s Patients Have Distinct Genetic Profiles, Study Shows

Adrenal Crisis Not a Major Cause of Death in Cushing’s Patients with Adrenal Insufficiency

Cushing’s Patients at Risk of Life-threatening Pulmonary Fungal Infection, Case Studies Suggest

Children with Pituitary Adenomas Have Similar Outcomes as Adult Patients, Study Shows

Study Describes Clinical Features that May Help Distinguish Silent Corticotroph Adenomas

Signifor LAR Shows Long-term Benefits for Cushing’s Disease Patients in Phase 3 Extension Trial

Study Describes 6 Common Surgical Failures in Cushing’s Disease Treatment

Relacorilant Effectively Manages Cortisol Effects in Cushing’s Patients, Interim Phase 2 Data Show

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