Alice Melao,  —

Addressing how a tissue absorbs and releases the contrast agent used in computed tomography (CT) scans – called a wash-out analysis – may help researchers determine if a tumor in the adrenal gland is benign or malignant, especially in the case of cortisol overproduction. This findings, reported in the study, “…

Strongbridge Biopharma is expecting a second patent on its Cushing’s syndrome therapy Recorlev (levoketoconazole). The signal it received was the U.S. Patent and Trademark Office completing a review of its new patent application for the cortisol synthesis inhibitor. The second patent, which would expire Jan. 10, 2026, would cover other conditions in…

Researchers studying two Chinese families affected by a rare form of Cushing’s syndrome found that two mutations affecting the ARMC5 gene — which had not been described to date — caused the disorder. Their study, “Whole-genome sequencing revealed armadillo repeat containing 5 (ARMC5) mutation in a Chinese family with…

Removing asymptomatic benign tumors that grow in the adrenal gland is safe and effectively reduces health-risks associated with these tumors in elderly patients, a case report suggests. The report, “Giant Cavernous Hemangioma of the Adrenal Gland in an Elderly Patient” was published at Internal Medicine, the…

The surgical removal of two-thirds of the pituitary gland is associated with high initial remission rates and low operative morbidity in patients with suspected Cushing’s disease, when no tumor is found on the gland during surgical exploration. Cushing’s disease (CD) is caused by increased levels of glucocoticosteroids, such as…

Ectopic Cushing’s syndrome can be challenging to diagnose, especially when it comes identifying the problem source. But appropriate hormone management protocols, used in combination with advanced imaging methods, may help physicians identify ectopic ACTH-producing tumors. The findings in a case report of a young man with ectopic Cushing’s syndrome were…

Doctors often prescribe somatostatin analogs to manage the hormonal imbalance that characterizes Cushing’s syndrome. However, in rare situations these medicines have paradoxically made patients worse than better. This recently happened with a 48-year-old Spanish woman whose Cushing’s syndrome was caused by an adrenal gland tumor that was producing excess adrenocorticotropic…

Nizoral (ketoconazole), an off-label inhibitor of steroid hormone production, can change the way the body distributes and absorbs Korlym (mifepristone), a new study finds. Because doctors sometimes prescribe both drugs simultaneously to Cushing’s syndrome patients, they need to better understand how these drugs interact to ensure the best doses…

The glucocorticoid receptor antagonist CORT125134 is safe and has shown preliminary signs of efficacy in healthy volunteers participating in a Phase 1 trial, say researchers in England. Their study, “Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double-Blind, Randomized, Placebo-Controlled Phase 1 Clinical…

Long-term follow-up and analysis of cortisol levels may help predict the recurrence of Cushing’s disease among patients who underwent surgery to remove their pituitary adenomas, a new study from India concludes. The study, “Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing’s disease,” appeared…