Andrea Lobo,  —

The first patient has opted to enter the open-label extension study of a Phase 2 trial testing SPI-62 in people with adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome, including Cushing’s disease. The announcement was made by SPI-62’s developer, Sparrow Pharmaceuticals, which is conducting a Phase 2 trial called…

A woman who developed Cushing’s syndrome caused by an adenoma — a benign tumor in the adrenal gland — saw her symptoms ease after she had surgery to remove the gland, scientists in Nepal reported. In rare cases, adrenal adenomas are associated with high levels of metanephrine, a byproduct of…

A 37-year-old woman diagnosed with Cushing’s disease following childbirth experienced a pulmonary embolism — a blockage in blood flow to the lungs that’s generally caused by blood clots — as one of the first symptoms of the rare disorder. According to clinicians, her case highlights that pulmonary embolism may…

A woman developed Cushing’s syndrome as a result of a rare pituitary tumor in the clivus region — a bone at the base of the skull — that produced excess levels of the adrenocorticotropic hormone (ACTH), a case study from China reports. This is a very rare case of…

A type of minimally invasive surgery to remove pituitary tumors through the nose, called endoscopic transsphenoidal surgery, was found to be safe and led to remission from Cushing’s disease, with patients seeing no recurrences, a study in China reports. The procedure involved identifying pituitary and tumor layers before the…

A 47-year-old woman with Cushing’s disease was initially misdiagnosed with an anxiety disorder, ultimately leading to her developing additional complications, scientists in China reported. The woman was diagnosed with Cushing’s disease after an ineffective psychiatric intervention, but continued taking high doses of psychiatric medications after surgery to remove a…

People with Cushing’s syndrome have a high disease burden linked to persistent symptoms of weight gain, pain, and anxiety, despite being treated, a recent study reported. These observations highlight the need for interventions that address these persistent symptoms and “underscore the importance of the patient’s perspective in clinical decision making…

A 46-year-old woman with a history of Cushing’s disease had a heart attack from an unusual cause — a tear in the coronary artery not due to trauma — and her disease may have contributed to the attack, scientists reported. A spontaneous tear, or dissection, in the wall of…

A 48-year-old woman in Belgium was found to have a hormone-producing tumor located in the sphenoid sinus, a hollow space behind the nose and between the eyes, in a rare case of Cushing’s syndrome. The tumor perfectly mimicked the biological characteristics of a classical pituitary adrenocorticotropic hormone (ACTH)-producing tumor on…

A Phase 4 clinical trial will assess the prevalence of excessive cortisol, or hypercortisolism, in people with difficult-to-treat type 2 diabetes, and the effectiveness of Korlym (mifepristone) in lowering cortisol levels, Corcept Therapeutics announced. The two-part, placebo-controlled CATALYST (NCT05772169) study is expected to enroll up to…