Marisa Wexler, MS,  senior science writer—

The Phase 3 GRACE trial that’s testing relacorilant in people with Cushing’s syndrome is expected to finish enrolling participants in the coming weeks, according to a recent corporate update from its developer, Corcept Therapeutics. Assuming the trial’s findings are positive, Corcept expects to use its data as the basis…

A man developed Cushing’s syndrome as a result of an interaction between two medications he was taking — an antiviral therapy to treat chronic infections and an inhaled steroid to manage asthma — according to a recent report. “This clinical case illustrates the importance of a meticulous review of all…

Magnetic resonance imaging (MRI) is a useful tool for pinpointing the location of a pituitary tumor that causes Cushing’s disease prior to surgery, a recent study reported. However, study findings indicate that bilateral inferior petrosal sinus sampling (BIPSS), an invasive diagnostic procedure, is more accurate for the initial…

People with recurrent Cushing’s disease who are treated with surgery are more likely to go into remission than patients given radiation therapy, a review study has found. “Based on the results of the current study, surgery should be considered as a second-line treatment for recurrent [Cushing’s disease] patients as…

Elderly people with Cushing’s syndrome often experience different symptoms than their younger counterparts, which suggests diagnosis may be more difficult with age, according to a recent study. “Several typical symptoms of [Cushing’s] were less frequent in the older patients as compared with the younger, including weight gain, skin…

Signifor (pasireotide) treatment was able to control symptoms of ectopic Cushing’s syndrome in a woman for years, according to a case report. The report, “Complete and sustained remission of hypercortisolism with pasireotide treatment of an adrenocorticotropic hormone (ACTH)-secreting thoracic neuroendocrine tumour: an n-of-1 trial,” was published in…

The case of a woman with adrenal gland cancer that caused Cushing’s syndrome in its advanced stages was described in a recent report. Authors noted this study highlights the difficulties in care for people with aggressive adrenal tumors, which often don’t cause noticeable symptoms until the disease is at a…

Throughout 2022, Cushing’s Disease News has brought you coverage of the latest developments in research and advances in treatment related to Cushing’s disease. We look forward to continuing to serve as a resource for the Cushing’s community going into 2023. Here is a list of the top 10…

Eating licorice can increase the amount of cortisol detected in saliva, but licorice consumption does not alter salivary levels of a cortisol metabolite called cortisone, a recent study has found. Cortisone also is less variable in response to other confounding variables, and researchers proposed salivary cortisone may be a more…

Measuring the ratio of cortisol to adrenocorticotropic hormone (ACTH) could help diagnose Cushing’s disease and other forms of Cushing’s syndrome, according to a recent study. “We think that it is possible to diagnose and screening [ACTH-independent Cushing’s syndrome] when CAR [cortisol-to-ACTH ratio] is elevated, and screening CD [Cushing’s disease]…