Marisa Wexler, MS,  senior science writer—

Recorlev (levoketoconazole) outperformed a placebo at normalizing urine cortisol levels among people with endogenous Cushing’s syndrome in the Phase 3 LOGICS trial. Top-line data from the study were announced in 2020. Full results have now been published in Pituitary in the study, “Levoketoconazole in the treatment…

The first participant has been dosed in a Phase 2 clinical trial testing SPI-62 as a treatment for people with ACTH-dependent forms of Cushing’s syndrome, including Cushing’s disease. That’s according to developer Sparrow Pharmaceuticals, which is evaluating the safety and effectiveness of the oral therapy. “Dosing our first…

Cushing’s disease-causing tumors that harbor a mutation in the TP53 gene are generally larger, more invasive, and linked to poorer clinical outcomes, a new study reports. The study, “TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome,” was published in Acta…

People with Cushing’s syndrome are at an increased risk of developing problems related to their bones or blood vessels due to excessive cortisol, a study highlighted. Problems in both these areas — the bones and the blood vessels — can also co-occur, its scientists reported. The study, “…

Rates of eye-related disorders called pachychoroid spectrum diseases are higher among people with Cushing’s syndrome than in the general population, a recent study reported. “We find that patients with Cushing’s syndrome have a high prevalence of any pachychoroid spectrum disease. Thus, in patients with Cushing’s syndrome there should be generally…

The case of a woman with Cushing’s syndrome whose symptoms included eyelid edema — swelling of the upper eyelids — was described in a recent report. Its authors described eyelid edema is “a significant sign” of Cushing’s, but also noted the symptom “has scarcely been reported in countries other than…

Children and adolescents with Cushing’s disease who have subclinical bleeding near their disease-driving tumors may respond differently to tests used to diagnose the disease, compared with patients without this bleeding, according to a new study. These differences may complicate the diagnostic workup of these patients and “should be incorporated…

For people with Cushing’s disease who have pituitary tumors that are not visible by MRI, careful exploratory surgery coupled with initial analyses to identify the location of a tumor can be used to achieve remission, a new study highlights. “The rate of MRI-negative [tumors] is reported to be between…

Mutations in the GPR101 and USP8 genes might have contributed to the growth of a particularly large and aggressive pituitary tumor that caused Cushing’s disease in a young girl. The case was described in the report, “Concurrent mutations of germline GPR101 and somatic USP8 in a pediatric giant…

Treatment with Isturisa (osilodrostat) normalized urine cortisol levels up to nearly 1.5 years in people with Cushing’s disease, according to data from the Phase 3 LINC-4 clinical trial. Data from another Phase 3 trial, LINC-3 (NCT02180217), showed that testosterone levels were generally stable among Cushing’s patients treated with…