Marisa Wexler, MS,  senior science writer—

For people with Cushing’s disease who have pituitary tumors that are not visible by MRI, careful exploratory surgery coupled with initial analyses to identify the location of a tumor can be used to achieve remission, a new study highlights. “The rate of MRI-negative [tumors] is reported to be between…

Mutations in the GPR101 and USP8 genes might have contributed to the growth of a particularly large and aggressive pituitary tumor that caused Cushing’s disease in a young girl. The case was described in the report, “Concurrent mutations of germline GPR101 and somatic USP8 in a pediatric giant…

Treatment with Isturisa (osilodrostat) normalized urine cortisol levels up to nearly 1.5 years in people with Cushing’s disease, according to data from the Phase 3 LINC-4 clinical trial. Data from another Phase 3 trial, LINC-3 (NCT02180217), showed that testosterone levels were generally stable among Cushing’s patients treated with…

The case of a woman with a rare form of Cushing’s syndrome whose main symptom was blurry vision was described in a recent report. The report, “Intermittent Blurry Vision: An Unexpected Presentation of Cushing’s Syndrome Due to Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH),” was published in…

Continuous treatment with Recorlev (levoketoconazole) helped to lower blood cholesterol levels in adults with endogenous Cushing’s syndrome, according to data from the Phase 3 LOGICS trial. Scientists at Xeris Biopharma, the company that markets Recorlev, presented the findings in the poster “Levoketoconazole in the Treatment of Endogenous…

High levels of the hormone precursor copeptin following surgery might be associated with remission in people with Cushing’s disease who do not later develop water balance disorders, new data indicate. However, the scientists stressed the need for further research on this potential biomarker, noting that copeptin levels after surgery…

The European Commission is expected to propose a new governing framework for health data next month, called the European Health Data Space (EHDS), with the aim of connecting national health systems to facilitate secure and efficient transfer of data across systems in different European nations. The move is expected to…

A new surgical technique pioneered at the Carling Adrenal Center in Florida allows for faster recovery of adrenal gland function after removal of an adrenal tumor. The adrenal glands are a pair of small, triangular organs located above the kidneys. They are responsible for producing a number of hormones that…

Treatment with Isturisa (osilodrostat) rapidly normalized cortisol levels, eased symptoms, and improved the quality of life for people with Cushing’s disease, according to data from the Phase 3 LINC-4 trial. “Isturisa enables most patients with Cushing’s disease to gain rapid control of their cortisol levels, which in turn…

A “block-and-replace” regimen of corticosteroid therapy can be used to manage COVID-19 in people with Cushing’s disease, a new report highlights. The report, “COVID-19 and Cushing’s disease in a patient with ACTH-secreting pituitary carcinoma,” was published in the journal Endocrinology, Diabetes and Metabolism Case Reports.