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A 71-year-old man diagnosed with ectopic Cushing’s syndrome was cured of the rare disorder after having both adrenal glands subjected to microwave ablation — a minimally-invasive procedure that uses electromagnetic energy to generate heat and destroy a small portion of tissue. The procedure immediately worked to lower the man’s elevated…

11oxC19 steroids, which are part of the androgen family of male sex hormones, are the primary drivers of hyperandrogenemia in women with Cushing’s disease, a study has found. Hyperandrogenemia, or high levels of androgens, in women with Cushing’s can lead to menstrual problems, acne, excessive body hair, and temporary…

Adrenal gland removal was key to controlling high cortisol levels and improving the quality of life of a 33-year-old male patient with Cushing’s disease and recurrent bone fractures. Researchers stressed that “when osteoporotic fractures occur at a young age, it is important to exclude secondary causes, such as Cushing’s…

The first participant has been dosed in a Phase 2 clinical trial testing SPI-62 as a treatment for people with ACTH-dependent forms of Cushing’s syndrome, including Cushing’s disease. That’s according to developer Sparrow Pharmaceuticals, which is evaluating the safety and effectiveness of the oral therapy. “Dosing our first…

Prolonged use of glucocorticoids to reduce inflammation triggered by facial dermal filler procedures likely caused Cushing’s syndrome in a 45-year-old woman, a case report describes. Long-term use of glucocorticoids should be avoided in such cases in favor of alternative treatments, its author noted. The report, “Case…

Cushing’s disease-causing tumors that harbor a mutation in the TP53 gene are generally larger, more invasive, and linked to poorer clinical outcomes, a new study reports. The study, “TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome,” was published in Acta…

A minimally invasive procedure called central venous sampling (CVS) may help in the diagnosis of Cushing’s disease in people with a disease-causing pituitary tumor that is not detected by MRI scans, a study suggests. CVS, which measures the levels of the adrenocorticotropic hormone (ACTH) from the brain’s pituitary gland,…

A woman developed Cushing’s syndrome following a medullary thyroid cancer that arose due to a mutation in a gene called RET, but her symptoms eased after starting Retsevmo (selpercatinib), a cancer medication, according to a report from France. The report, “Rapid and long-lasting response to selpercatinib of paraneoplastic Cushing’s…

Problem-solving therapy (PST) may improve coping skills and mental health in people with Cushing’s disease by reducing negative attitudes toward problem-solving, depressive symptoms, and perceived stress, a new study has found. The study, “Problem-solving therapy can reduce psychological distress in patients with Cushing’s disease: a randomized controlled trial,”…

Single-cell analysis of non-cancerous pituitary gland tumors that cause Cushing’s disease identified a novel therapeutic target with the potential to suppress tumor cell growth, a study has revealed. Although cells from such tumors, called adenomas, had excess production of noxa — a protein that stimulates cell death — noxa…