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Treatment with Isturisa (osilodrostat) caused adrenal insufficiency — a condition in which the adrenal glands are unable to produce enough of certain hormones — in a 41-year-old woman with Cushing’s disease, a case report showed. While the researchers noted that “monitoring for side effects and biochemical and clinical…

A woman developed Cushing’s syndrome five years after being diagnosed with a neuroendocrine tumor of the cervix, according to a report from the U.S. This is a rare type of tumor for which “the options for treatment are few and not necessarily curative,” the report’s authors wrote. “Managing the…

Not many people who are very obese have Cushing’s syndrome, but a low-dose dexamethasone test may help distinguish who has the disease from who doesn’t before weight loss surgery, a Turkish study has reported. The study, “Assessment of the diagnostic performance of the 1 mg dexamethasone suppression test in…

A young man switched his standard diet to a ketogenic, or “keto,” diet that’s low in carbohydrates and high in fats to lose weight, and saw some of his symptoms of Cushing’s disease ease, according to a new report. But he wasn’t diagnosed until his symptoms came back or…

Eating licorice can increase the amount of cortisol detected in saliva, but licorice consumption does not alter salivary levels of a cortisol metabolite called cortisone, a recent study has found. Cortisone also is less variable in response to other confounding variables, and researchers proposed salivary cortisone may be a more…

PROP1, a pituitary gland protein that regulates gene activity related to hormone production, may play a role in the development of noncancerous tumors that cause Cushing’s disease, a small preliminary study suggested. According to researchers, PROP1 may be a therapeutic target for pituitary tumors. Future studies involving a larger…

Measuring the ratio of cortisol to adrenocorticotropic hormone (ACTH) could help diagnose Cushing’s disease and other forms of Cushing’s syndrome, according to a recent study. “We think that it is possible to diagnose and screening [ACTH-independent Cushing’s syndrome] when CAR [cortisol-to-ACTH ratio] is elevated, and screening CD [Cushing’s disease]…

Recorlev (levoketoconazole) outperformed a placebo at normalizing urine cortisol levels among people with endogenous Cushing’s syndrome in the Phase 3 LOGICS trial. Top-line data from the study were announced in 2020. Full results have now been published in Pituitary in the study, “Levoketoconazole in the treatment…

Long-term treatment with Recorlev (levoketoconazole) safely leads to sustained reductions in cortisol levels, disease signs and symptoms, and improvements in quality of life in adults with endogenous Cushing’s syndrome, according to nearly two years of data from the Phase 3 SONICS trial. Treatment benefits were generally maintained or deepened…

“Mini pituitary tumors” derived from patients, including those with Cushing’s disease, mimic several features of the individual’s tumor, including response to treatments, a study shows. These pituitary tumor-like organoids can serve as models for studies of the underlying molecular mechanisms of Cushing’s disease and to screen for the most…