Etomidate helped normalize dangerously high cortisol levels in a woman with Cushing’s syndrome who had an adrenal gland tumor before she having surgery to remove it, a recent case report shows. “In its severe form, Cushing’s syndrome is a medical emergency that must be rapidly controlled. Etomidate is both safe…
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A 44-year-old man developed exogenous, or treatment-related, Cushing’s syndrome, after taking an herbal supplement called Nhan Sam Tuyet Lien, which contained undisclosed amounts of glucocorticoids, a case study reports. His symptoms eased after he stopped taking the supplement and started taking prednisone. “This case highlights the importance of history taking…
People with Cushing’s syndrome, which is caused by excessive levels of the hormone cortisol in the body, may experience changes in brain activity during sleep, especially in the first half of their sleep cycle, a study has found. Adrenocorticotropic hormone (ACTH), which drives the adrenal glands sitting atop the kidneys…
Alterations in the activity of a signaling system called RAAS in fatty tissue could contribute to high blood pressure in people with Cushing’s syndrome, according to a recent report. Data showed gene activity associated with renin-angiotensin-aldosterone-system (RAAS) was altered in fatty tissue from Cushing’s patients relative to people without the…
Despite repeatedly testing negative for high cortisol levels on standard lab tests, a woman in her 30s was found to have Cushing’s syndrome after undergoing a specialized blood analysis. That test allowed doctors to measure the levels of the hormone cortisol — too much of which is a hallmark of…
Surgery to remove a tumor in the brain’s pituitary gland cured about a third of people with Cushing’s disease in a recent Thai study, a remission rate markedly lower than the 80-90% rate reported in other studies. Researchers believe the low rate might have been due to some surgeries…
While people with Cushing’s syndrome often experience hypertension, or high blood pressure, and diabetes — two conditions that put them at higher risk of developing cardiovascular diseases — tumor removal surgery was found to ease these conditions in a new study from Tunisia. Indeed, most patients saw improvements within one…
Long-term treatment with Isturisa (osilodrostat) led to a sustained normalization in cortisol levels, symptom relief, and improved quality of life for people with Cushing’s disease, according to the full results from the LINC 4 clinical trial and its extension phase. “These data provide further evidence of the durable clinical…
A diagnostic test utilizing desmopressin, an artificial form of a hormone that’s used to control excessive thirst and urination and prevent dehydration, can help to accurately identify Cushing’s disease, a new study reports. The study, “Enhancing Cushing’s disease diagnosis: exploring the impact of desmopressin on ACTH…
The first patient has opted to enter the open-label extension study of a Phase 2 trial testing SPI-62 in people with adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome, including Cushing’s disease. The announcement was made by SPI-62’s developer, Sparrow Pharmaceuticals, which is conducting a Phase 2 trial called…
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