News

Surgery to remove a tumor in the brain’s pituitary gland cured about a third of people with Cushing’s disease in a recent Thai study, a remission rate markedly lower than the 80-90% rate reported in other studies. Researchers believe the low rate might have been due to some surgeries…

While people with Cushing’s syndrome often experience hypertension, or high blood pressure, and diabetes — two conditions that put them at higher risk of developing cardiovascular diseases — tumor removal surgery was found to ease these conditions in a new study from Tunisia. Indeed, most patients saw improvements within one…

Long-term treatment with Isturisa (osilodrostat) led to a sustained normalization in cortisol levels, symptom relief, and improved quality of life for people with Cushing’s disease, according to the full results from the LINC 4 clinical trial and its extension phase. “These data provide further evidence of the durable clinical…

A diagnostic test utilizing desmopressin, an artificial form of a hormone that’s used to control excessive thirst and urination and prevent dehydration, can help to accurately identify Cushing’s disease, a new study reports. The study, “Enhancing Cushing’s disease diagnosis: exploring the impact of desmopressin on ACTH…

The first patient has opted to enter the open-label extension study of a Phase 2 trial testing SPI-62 in people with adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome, including Cushing’s disease. The announcement was made by SPI-62’s developer, Sparrow Pharmaceuticals, which is conducting a Phase 2 trial called…

A newborn girl with a rare genetic disorder called McCune-Albright syndrome (MAS) developed Cushing’s syndrome, according to researchers in Turkey. While Cushing’s syndrome in the context of MAS is linked to a poor prognosis, no specific guidelines exist for diagnosing and treating these rare cases. The newborn’s condition improved following…

Cabergoline, which is often used as an off-label therapy for recurrent or persistent Cushing’s disease, is not associated with a high risk for impulse control disorders(ICDs), a concern raised about this kind of medication. These are the findings of a small study in Turkey that suggests cabergoline “still holds…

People with Cushing’s disease who achieve remission — no matter how long that takes — are more likely to live a longer life than are patients who have active disease, a 20-year study found. Achieving remission, which is when symptoms ease or disappear, was linked to fewer deaths, also…

The Phase 3 GRACE trial testing relacorilant in people with Cushing’s syndrome has completed enrollment and data from it is expected next year, according to a recent corporate update from Corcept Therapeutics, its developer. The company plans to submit a new drug application (NDA) to U.S. authorities to market…

People with Cushing’s syndrome, including those with Cushing’s disease, exhibit immune system alterations that could contribute to some symptoms of the disease, a small study suggests. Analyses of immune cells from Cushing’s patients indicated signs of both systemic (whole body) inflammation as well as immunosuppression, which scientists believe might…