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Roughly half of people worldwide with Cushing’s syndrome see their diagnosis delayed by more than two years despite showing symptoms of the disease, according to a new international survey. Researchers found that this delay perhaps occurs because doctors dismiss some of the hormonal disorder’s initial symptoms — which…

Certain molecules called microRNAs (miRNAs) that act to regulate protein production could underlie certain Cushing’s syndrome subtypes, a study found. Better understanding the role of these miRNAs and the proteins they affect will help facilitate a better understanding of disease processes, as well as the development of better treatments for…

Signifor (pasireotide), a treatment for Cushing’s disease patients for whom surgery failed or is not an option, significantly reduces the size of benign pituitary tumors in more than 40% of people with the condition, according to a review of published studies. However, the researchers noted that tumor reduction was…

People with active Cushing’s disease show increased production of red blood cells due to the presence of a type of altered blood stem cell that show abnormal activation of glucocorticoid receptor (GR) signaling, a study shows. The GR is the receptor protein activated by glucocorticoids, or steroid hormones, including…

Elevated blood sugar levels and a failure to respond properly to insulin – the hormone that helps regulate blood sugar – are common features in people with Cushing’s syndrome, according to a Chinese report. Its authors suggest that measures of insulin sensitivity and a response from beta-cells – the…

The 2008 Endocrine Society Practice guideline remains a valid tool for defining the clinical signs and at-risk groups that should undergo screening for Cushing’s syndrome, according to a 10-year prospective German study. However, while 73% of the Cushing’s diagnoses were made in the at-risk groups defined by the guideline, the…

A 70-year-old woman with ectopic Cushing’s syndrome was successfully treated for COVID-19 with intravenous immunoglobulins (IVIg) — a therapy prepared from the blood of thousands of healthy donors that contains a mixture of antibodies — according to a case report. Given the lack of guidelines for the management of…

The case of a woman with Cushing’s syndrome whose symptoms included eyelid edema — swelling of the upper eyelids — was described in a recent report. Its authors described eyelid edema is “a significant sign” of Cushing’s, but also noted the symptom “has scarcely been reported in countries other than…

Removing a pituitary tumor through the nostrils with an endoscope led to shorter recovery times for patients with Cushing’s disease than for those who had the surgery through the traditional microscopic approach, a study reports. However, similar remission, recurrence, and complication rates were found between patients, regardless of the…

Nonprofits, scientists, governmental organizations, and the rare disease drug development industry have long cited 7,000 as the average number of rare diseases in the world. But a new analysis shows there are as many as 10,867 rare diseases globally. And that…