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Treatment with Isturisa (osilodrostat) for 1.5 years or longer kept urine cortisol levels close to normal in patients with Cushing’s disease, and this translated into fewer symptoms with no new side effects, a study has found. The findings come from an extension of LINC-3 (NCT02180217), a Phase…

Researchers have identified risk factors for kidney impairment in adults with Cushing’s syndrome after they undergo surgery to remove their adrenal glands. These factors include having low pre-operative adrenocorticotropic hormone (ACTH) levels or taking higher steroid replacement doses after the surgery. “Disease activity represented by ACTH levels or the steroid…

The hormonal changes that occur during pregnancy and at childbirth may trigger the reappearance of Cushing’s disease in the mother following birth, a recent case report indicated. This is the first reported case of a woman with dormant Cushing’s disease during pregnancy who became symptomatic following delivery, according to…

Patients who undergo surgery for Cushing’s syndrome may have a high risk of blood clots and should receive preventive anti-blood clotting treatments for at least one month, according to a recent case report. Researchers also suggested these patients should be closely monitored following surgery. The report described the case of…

Rates of eye-related disorders called pachychoroid spectrum diseases are higher among people with Cushing’s syndrome than in the general population, a recent study reported. “We find that patients with Cushing’s syndrome have a high prevalence of any pachychoroid spectrum disease. Thus, in patients with Cushing’s syndrome there should be generally…

Prolonged exposure to the hormone cortisol during periods of active disease in Cushing’s patients is linked to lower long-term quality of life but not to cognitive problems after remission, a study shows. The study, “Impaired quality of life, but not cognition, is linked to a history of chronic…

Roughly half of people worldwide with Cushing’s syndrome see their diagnosis delayed by more than two years despite showing symptoms of the disease, according to a new international survey. Researchers found that this delay perhaps occurs because doctors dismiss some of the hormonal disorder’s initial symptoms — which…

Certain molecules called microRNAs (miRNAs) that act to regulate protein production could underlie certain Cushing’s syndrome subtypes, a study found. Better understanding the role of these miRNAs and the proteins they affect will help facilitate a better understanding of disease processes, as well as the development of better treatments for…

Signifor (pasireotide), a treatment for Cushing’s disease patients for whom surgery failed or is not an option, significantly reduces the size of benign pituitary tumors in more than 40% of people with the condition, according to a review of published studies. However, the researchers noted that tumor reduction was…

People with active Cushing’s disease show increased production of red blood cells due to the presence of a type of altered blood stem cell that show abnormal activation of glucocorticoid receptor (GR) signaling, a study shows. The GR is the receptor protein activated by glucocorticoids, or steroid hormones, including…