Using topical creams with high corticosteroid concentrations to manage skin rash in infants can lead to the development of drug-related secondary Cushing’s syndrome, a case report shows. Therefore, the public needs to be made more aware of the adverse effects of these treatments in this young population, researchers say.
Most Cushing’s disease patients who achieve remission experience overproduction of thyroid hormones, followed by a return to normal levels, within 12 months after surgery to remove a pituitary tumor, according to new research. The findings also showed that changes in thyroid hormones are associated with serum levels of cortisol. The research, “…
Cushing’s syndrome might lead to congestive heart failure — when the heart pumps blood inefficiently, causing stress in internal organs and fluid retention — in pregnant women, a case report suggests. If doctors suspect Cushing’s syndrome during pregnancy, they should make timely decisions to avoid complications for the…
Screening newborns for genetic diseases with treatments that can prevent crippling or deadly progression, especially for rare disorders, has a ways to go in the United States. No state today tests for all 35 disorders recommended under a federal screening panel, and even in those that come close, rare…
Treatment with Signifor (pasireotide) over 12 months reduced urinary cortisol levels and enabled full disease control in a subset of 14 patients with Cushing’s disease who were monitored at an Italian center and taking part in a Phase 3 trial, a study has found. The study, “…
Oklahoma suffers more tornadoes than any other state, has the highest per-capita rate of women in U.S. prisons, ranks second in the number of teen births per 100,000 teenage girls, and has the nation’s third-highest rate of uninsured residents — with 13.9% of all Oklahomans lacking health coverage. As if…
People with Cushing’s disease who have a bilateral adrenalectomy should be regularly assessed for their adrenocorticotrophic hormone (ACTH) levels, and undergo periodic magnetic resonance imaging (MRI) analysis of residual tumors, to help predict and possibly detect Nelson’s syndrome, according to a new study. The findings also showed…
Repeat transsphenoidal surgery (TSS) in patients experiencing recurrence of Cushing’s disease after the initial procedure is effective and associated with high rates of sustained remission, according to a new study. The research, “Outcomes After Repeat Transsphenoidal Surgery for Recurrent Cushing Disease: Updated,” appeared in the journal…
Recordati has acquired worldwide rights over Novartis‘ investigational therapy osilodrostat (LCI699), being developed for the treatment of endogenous Cushing’s disease. The agreement also covers Signifor (pasireotide), an approved treatment for adults with Cushing’s disease who failed surgery or who were not eligible for surgery,…
A new international consortium based in Paris, and funded largely by the 28-member European Union, intends to speed the diagnosis of rare diseases, while also accelerating the development of treatments for the 95% of such illnesses that currently don’t have one. The European Joint Programme on Rare Diseases (EJP…
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