News

Bilateral adrenalectomy, in which the adrenal glands are removed, has a bigger negative impact on the quality of life of patients with Cushing’s disease than other treatment options, a recent study suggests. This may be due to the longer exposure to high levels of cortisol in these patients, which is…

Treatment with fluconazole after cabergoline eased symptoms and normalized cortisol levels in a patient with recurrent Cushing’s disease who failed to respond to ketoconazole, a case study reports. The case report, “Fluconazole as a Safe and Effective Alternative to Ketoconazole in Controlling Hypercortisolism of Recurrent Cushing’s Disease:…

More than 25 percent of women with Cushing’s disease experienced their first symptoms within one year of giving birth, a small study by the Pacific Neuroscience Institute found. The findings suggest a possible causal relationship between the biological stress of pregnancy and Cushing’s disease (CD), with more than a two-fold…

More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…

Cushing’s syndrome patients deemed in biological remission are rarely functionally cured, continuing to report low quality of life scores, chronic depression, and the need for specific working arrangements in the long term, a study reports. Researchers point to neurocognitive damage — mainly depression — as a major player in…

A precise form of radiation therapy, known as Gamma Knife radiosurgery, produces a low rate of adverse radiation effects and provides good tumor control when used as an upfront treatment strategy in Cushing’s disease patients, an international study suggests. The study, “Upfront Gamma Knife radiosurgery for…

High levels of inflammatory cytokines — molecules that mediate the body’s immune response — may increase the risk of metabolic and heart disease in subclinical Cushing’s syndrome patients, a retrospective study shows. The study, “Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing’s syndrome and healthy controls,”…

In Cushing’s disease (CD), depression is correlated with body image distortion and lower self-esteem, according to an Indian study. Physicians should be attentive to symptoms of mental disturbances in CD patients to provide them a better prognosis. The research, “A Study on Psychiatric Disorders, Body Image…

The Endocrine Society has selected 13 leaders in the endocrinology field as winners of its prestigious 2019 Laureate Awards. Among the recipients is James W. Findling, MD, an expert in Cushing’s disease. Each recipient will be presented with the award at ENDO 2019,…

Medical therapy using cabergoline is an option for treating patients with persistent or recurrent Cushing’s disease after transsphenoidal surgery, new research from India shows. The study, “Effect of cabergoline monotherapy in Cushing’s disease: an individual participant data meta‑analysis,” was published in the Journal of Endocrinological Investigation. Cushing’s disease is most…