Long-term exposure to high levels of the adrenocorticotropic hormone (ACTH) may lead to a recurrence of Cushing’s disease even after surgical treatment, according to a case report. Detailed guidelines are needed to help physicians determine the best approach to treating patients with Cushing’s and preventing disease recurrence. The study, “…
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The production of adenocorticotropic hormone (ACTH) by the placenta during pregnancy may complicate and worsen Cushing’s syndrome manifestations, a case report shows. The study, “Exacerbation of Cushing’s syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit” was published in the journal Endocrinology,…
About 100 scientists, researchers, pharmaceutical executives, and others will converge on Austria’s capital city early next month for the 2nd International Congress on Advanced Treatments in Rare Diseases. The March 4-5 meeting, to take place at the Hilton Am Stadtpark Vienna, features 27 speakers on a variety of disorders…
Mutations in the GNAS gene might indicate patients with subclinical Cushing’s syndrome — mild cortisol elevation without physical signs of Cushing’s — whose disease is caused by distinct mechanisms of other Cushing’s syndrome patients. Screening for GNAS gene mutations may help diagnose patients with this type of Cushing’s syndrome and improve their outcomes,…
Cushing’s syndrome patients who undergo adrenal surgery are more likely to have venous thromboembolism — blood clots that originate in the veins — than patients who have the same procedure for other conditions, a study suggests. Physicians should consider preventive treatment for this complication in Cushing’s syndrome patients who are…
A study reports that intravenous infusion with etomidate can stabilize dangerously high cortisol in Cushing’s syndrome patients experiencing episodes of cortisol excess. The study, “Continuous Etomidate Infusion for the Management of Severe Cushing Syndrome: Validation of a Standard Protocol,” was published in Journal of the Endocrine Society. Cushing’s…
Scores of events are afoot worldwide to mark Feb. 28, Rare Disease Day 2019. The activities aim to raise awareness about rare diseases and the millions of people — estimates run as high as 350 million — they are thought to impact. Across countries, patients, caregivers and advocates will paint faces, wear…
Laparoscopic adrenalectomy — a minimally invasive procedure that removes the adrenal glands through a tiny hole in the abdomen — can be safely performed in obese patients with Cushing’s syndrome, a retrospective study reports. The surgery resolved symptoms in 95% of cases, reducing cortisol levels, lowering blood pressure, and leading to…
Ocular hypertension — increased blood pressure inside the eye — might be a secondary symptom of Cushing’s disease, caused by long-term exposure to high cortisol levels, a case report shows. The study, “Ocular hypertension secondary to high endogenous steroid load in Cushing’s disease,” was published in BMJ…
Optical imaging that measures water content and blood volume in the cheek might be an efficient and non-invasive method to assess short- and long-term remission in people with Cushing’s disease, according to a study. The study, “Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease…
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