Excess cortisol in cortisol-producing adenomas may be caused by a lack of chemical modifications in a gene involved in cortisol synthesis, new research found. The study shows that DNA methylation, a type of modification in the DNA whose function is to reduce protein expression, in the aldosterone synthase gene is significantly…
Patients with Cushing’s disease or other pituitary tumors who undergo radiotherapy after surgery have a higher chance of developing secondary brain tumors, a new study shows. Such patients should be followed for longer periods, and by multidisciplinary clinical teams, ensuring proper and prompt care. The study, “Secondary Intracranial Tumors…
The multicenter, international Phase 3 SONICS study testing the safety and effectiveness of Strongbridge Biopharma’s therapy candidate Recorlev (levoketoconazole) for endogenous Cushing’s syndrome has reached its goal of enlisting 90 participants, which completes the enrollment phase. Due to strong interest in the study, a…
The recent identification of genetic mutations linked to Cushing disease (CD) and its unbalanced molecular mechanisms has opened new potential therapeutic avenues for an illness with a large unmet medical need. In the study, “Recent advances in understanding Cushing disease: resistance to…
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