News

More biomarkers needed to support Cushing’s syndrome diagnosis

More biomarkers are necessary for the differential diagnosis of Cushing’s syndrome subtypes in children and adolescents, as well as to predict disease progression more effectively — allowing for quicker and less invasive assessments of patients. That’s according to the results of a new, large, observational study, which also reported on…

Diabetes med metformin studied as Cushing’s treatment

Metformin, a medicine used mostly to treat type 2 diabetes, eased the signs of Cushing’s disease in cells and in a mouse model, a study showed. “These findings suggest metformin as a potential drug for the treatment of Cushing’s disease,” researchers wrote in the study, “Metformin…

Ectopic Cushing’s tied to rare yolk sac tumor in pancreas

A 27-year-old woman in China has become the first reported case of an adult developing ectopic Cushing’s syndrome as a result of a rare yolk sac tumor in the pancreas producing high levels of adrenocorticotropic hormone (ACTH) precursors, according to researchers. A yolk sac tumor is a rare, malignant tumor…

Top 10 Cushing’s disease stories of 2023

In 2023, Cushing’s Disease News brought readers comprehensive coverage of the latest scientific research and developments in treatment for Cushing’s disease. Here are the 10 most-read news stories of 2023, along with a brief description of each. We look forward to continuing to serve as a resource for…

Locating tumors by IPSS may not lead to better surgery outcomes

Accurately locating tumors in the brain’s pituitary gland by inferior petrosal sinus sampling or IPSS — an invasive test that’s been considered the gold standard for diagnosing Cushing’s disease — may not necessarily lead to better outcomes after surgery, according to a new meta-analysis. While IPSS correctly determined…

Woman needed 2 tumor surgeries to resolve rare case of Cushing’s

A 32-year-old woman with a rare case of two pituitary tumors required two surgeries to treat her Cushing’s disease, according to a recent report. Her disease was caused by one tumor, or adenoma, that resulted in high amounts of the adrenocorticotropic hormone (ACTH). The other tumor, called a prolactinoma, causes…

Cushing’s syndrome complicated by tumors secreting 2 hormones

Cushing’s syndrome in a 45-year-old woman was complicated by primary aldosteronism, the result of tumors in the adrenal glands secreting both cortisol and aldosterone, according to a case reported in China. Aldosteronism occurs when the adrenal glands produce high levels of aldosterone, a hormone that regulates blood pressure and balances…