Treatment with Isturisa (osilodrostat) is generally well tolerated and effective at reducing cortisol levels and easing Cushing’s disease symptoms in Asian patients, with results similar to those seen in non-Asian patients. That’s according to a new study that compared both patient populations in two Phase 3 clinical trials…
News
A rare, highly malignant kidney tumor turned out to be the cause of Cushing’s syndrome in an 18-year-old man whose case was described in a recent study. The man had classic symptoms of Cushing’s, including weight gain, fat buildup, and skin changes that resolved after the kidney harboring the…
A new report from researchers at the Montefiore Medical Center in New York details the cases of two women with ectopic Cushing’s secondary to diffuse idiopathic neuroendocrine cell hyperplasia, or DIPNECH — a rare lung disease that may lead to the development of tumors that in extremely rare cases may…
Diagnosing and managing Cushing’s syndrome in children can be complex and takes careful management, according to a case report and review study that described the difficult diagnostic process for a boy who was ultimately found to have Cushing’s disease that could be managed through surgery. “Our case was illustrative…
A low-dose dexamethasone test, which is commonly used to diagnose Cushing’s syndrome, can effectively detect the rare condition in people with obesity, according to a new study. However, despite the test’s effectiveness, the proportion of patients who ultimately were diagnosed with Cushing’s was low, at 0.2%. Given that finding,…
People with Cushing’s disease have more fat in their kidneys and around the heart than those with other conditions with elevated cortisol, a study suggests. Across all the people evaluated, including those with Cushing’s syndrome, levels of these types of fat were associated with metabolic factors, such as diabetes,…
A diagnostic test using desmopressin, an artificial form of a naturally occurring hormone, can help to accurately identify people with Cushing’s disease, a study reports. Easier than the current gold standard for diagnosing this disease, the desmopressin stimulation test might “reduc[e] the reliance on invasive procedures and provid[e] a…
Cushing’s disease appears to be on the rise in Iceland, a study finds, underscoring the importance of an early diagnosis. “Advances in diagnostic and treatment options is probably the strongest cause of increased incidence in the later years, but other factors such as genetics can also play a role,”…
A 76-year-old man in Greece developed ectopic Cushing’s syndrome due to an advanced prostate cancer that started producing the adrenocorticotropic hormone (ACTH), leading to unusual symptoms such as muscle weakness, slowed thinking, and low potassium levels. Despite immediate treatment, his clinical condition worsened, and he eventually died. It’s a…
People often do not recognize the typical symptoms and features of Cushing’s syndrome, regardless of their severity, which contributes to a delay in diagnosis, a study found. Moreover, there was a discrepancy between the number of symptoms reported by individuals with Cushing’s and those assessed by clinicians — with…
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