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People with Cushing’s syndrome have a high disease burden linked to persistent symptoms of weight gain, pain, and anxiety, despite being treated, a recent study reported. These observations highlight the need for interventions that address these persistent symptoms and “underscore the importance of the patient’s perspective in clinical decision making…

A rare case of Cushing’s syndrome in a 3-month-old girl was traced to a medication error involving glucocorticoid, with the infant having been given an oral liquid formulation of omeprazole, prepared by a local pharmacist, that contained small amounts of the steroid hormone. The baby was being treated with omeprazole —…

A 46-year-old woman with a history of Cushing’s disease had a heart attack from an unusual cause — a tear in the coronary artery not due to trauma — and her disease may have contributed to the attack, scientists reported. A spontaneous tear, or dissection, in the wall of…

Low-grade inflammation persisted in people with Cushing’s syndrome one year after surgery to remove disease-causing tumors that led to excess cortisol, the hallmark of the condition, a recent study revealed. High levels of inflammatory markers were associated significantly with post-surgical obesity, high blood sugar levels, and worse long-term muscle function,…

A federal court ruling in Texas that reversed the U.S. Food and Drug Administration’s (FDA) 23-year-old approval of mifepristone has been met with deep concern by the Endocrine Society. Mifepristone, the active ingredient in Mifeprex, is used to end a pregnancy. It’s also the active ingredient of Korlym,…

A 48-year-old woman in Belgium was found to have a hormone-producing tumor located in the sphenoid sinus, a hollow space behind the nose and between the eyes, in a rare case of Cushing’s syndrome. The tumor perfectly mimicked the biological characteristics of a classical pituitary adrenocorticotropic hormone (ACTH)-producing tumor on…

A Phase 4 clinical trial will assess the prevalence of excessive cortisol, or hypercortisolism, in people with difficult-to-treat type 2 diabetes, and the effectiveness of Korlym (mifepristone) in lowering cortisol levels, Corcept Therapeutics announced. The two-part, placebo-controlled CATALYST (NCT05772169) study is expected to enroll up to…

Participants are poised for Cushing’s Awareness Day, observed every April 8, to call attention to Cushing’s disease, a disorder that causes a host of physical, mental, and hormonal issues. The day also marks the birthday of Harvey Cushing, widely considered the father of neurosurgery, who first described Cushing’s disease…

A 28-year-old pregnant woman was diagnosed with Cushing’s caused by advanced adrenal gland cancer, a rare malignancy with a poor prognosis, scientists reported. Her case highlights the difficulties in diagnosing and treating such tumors, particularly during pregnancy, when hormonal changes can camouflage its symptoms. “It is reported that benign and malignant…

The risk of consuming supplements was recently highlighted in a case of a woman with Cushing’s syndrome caused by prolonged use of an over-the-counter arthritis product containing a glucocorticoid. The patient was ultimately diagnosed with Cushing’s based on her typical disease features together with her long exposure to the…