In rare cases, proximal muscle weakness may be the only indication of Cushing’s disease, a recent case report showed. The patient, a 36-year-old man, was initially misdiagnosed with dermatomyositis, a rare disease that causes muscle inflammation and skin rash. The report, “Proximal muscle weakness as the sole manifestation…
News
A rare tumor in the prostate gland triggered Cushing’s syndrome in a man, a case study from Lebanon reports. The report, “ACTH-secreting metastatic prostate cancer with neuroendocrine differentiation,” was published in BMJ Case Reports. Cushing’s syndrome is caused by an excess of cortisol in the body. It sometimes…
Throughout 2022, Cushing’s Disease News has brought you coverage of the latest developments in research and advances in treatment related to Cushing’s disease. We look forward to continuing to serve as a resource for the Cushing’s community going into 2023. Here is a list of the top 10…
People with pituitary gland tumors that cause Cushing’s disease are at higher risk of developing ocular hypertension — increased blood pressure inside the eyes — than those with other types of pituitary tumors, according to a study in China. Its authors highlighted the importance of these results in ensuring ophthalmologists…
Young children may be at high risk of developing Cushing’s syndrome after having a highly potent topical glucocorticoid applied to the skin, two case reports show. The researchers emphasized that physicians who prescribe these medications must be aware for this potential side effect and closely monitor patients. They also…
Adults and children with endogenous Cushing’s syndrome in Colombia will have access to Metopirone (metyrapone), the first Cushing’s treatment to be approved in the country, HRA Pharma Rare Diseases, which developed and markets the treatment, announced. With this registration, Colombia joins several other countries, including in Europe, the…
The hormone aldosterone may contribute to high blood pressure in people with subclinical hypercortisolism — those who have high levels of cortisol due to tumors in the adrenal glands, but do not have overt symptoms of Cushing’s syndrome. Aldosterone, excessively produced and released by the adrenal glands in these patients,…
Isturisa (osilodrostat), a medication that blocks cortisol production, was effective in a group of patients with intense and severe hypercortisolism caused by ectopic Cushing’s syndrome, an observational study reported. Of a total of 33 patients, 11 received Isturisa as a first-line monotherapy,…
A second transsphenoidal surgery (TSS) in Cushing’s disease patients with or without visible MRI lesions in the brain’s pituitary gland led to reasonable remission rates, a study reports. Of 42 patients, 29 (69%) achieved immediate remission after repeated surgery, with no difference in remission…
A rare plurihormonal tumor in the brain’s pituitary gland — one that produced and released both adrenocorticotrophic hormone (ACTH) and growth hormone — caused Cushing’s disease in a woman in her 30s, a case study reported. Given the rarity of tumors in which both types of hormones are produced,…
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