News

Single-cell analysis of non-cancerous pituitary gland tumors that cause Cushing’s disease identified a novel therapeutic target with the potential to suppress tumor cell growth, a study has revealed. Although cells from such tumors, called adenomas, had excess production of noxa — a protein that stimulates cell death — noxa…

People with Cushing’s syndrome are at an increased risk of developing problems related to their bones or blood vessels due to excessive cortisol, a study highlighted. Problems in both these areas — the bones and the blood vessels — can also co-occur, its scientists reported. The study, “…

Treatment with Isturisa (osilodrostat) for 1.5 years or longer kept urine cortisol levels close to normal in patients with Cushing’s disease, and this translated into fewer symptoms with no new side effects, a study has found. The findings come from an extension of LINC-3 (NCT02180217), a Phase…

Researchers have identified risk factors for kidney impairment in adults with Cushing’s syndrome after they undergo surgery to remove their adrenal glands. These factors include having low pre-operative adrenocorticotropic hormone (ACTH) levels or taking higher steroid replacement doses after the surgery. “Disease activity represented by ACTH levels or the steroid…

The hormonal changes that occur during pregnancy and at childbirth may trigger the reappearance of Cushing’s disease in the mother following birth, a recent case report indicated. This is the first reported case of a woman with dormant Cushing’s disease during pregnancy who became symptomatic following delivery, according to…

Patients who undergo surgery for Cushing’s syndrome may have a high risk of blood clots and should receive preventive anti-blood clotting treatments for at least one month, according to a recent case report. Researchers also suggested these patients should be closely monitored following surgery. The report described the case of…

Rates of eye-related disorders called pachychoroid spectrum diseases are higher among people with Cushing’s syndrome than in the general population, a recent study reported. “We find that patients with Cushing’s syndrome have a high prevalence of any pachychoroid spectrum disease. Thus, in patients with Cushing’s syndrome there should be generally…

Prolonged exposure to the hormone cortisol during periods of active disease in Cushing’s patients is linked to lower long-term quality of life but not to cognitive problems after remission, a study shows. The study, “Impaired quality of life, but not cognition, is linked to a history of chronic…

Roughly half of people worldwide with Cushing’s syndrome see their diagnosis delayed by more than two years despite showing symptoms of the disease, according to a new international survey. Researchers found that this delay perhaps occurs because doctors dismiss some of the hormonal disorder’s initial symptoms — which…

Certain molecules called microRNAs (miRNAs) that act to regulate protein production could underlie certain Cushing’s syndrome subtypes, a study found. Better understanding the role of these miRNAs and the proteins they affect will help facilitate a better understanding of disease processes, as well as the development of better treatments for…