Treatment with Isturisa (osilodrostat) led to a rapid and sustained reduction in cortisol levels and was well-tolerated in people with Cushing’s disease, according to newly published data from the LINC-3 clinical trial. The results were published in The Lancet Diabetes & Endocrinology, in the article “…
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The first patient has been enrolled in Corcept Therapeutics‘ Phase 3 GRADIENT trial, which is evaluating relacorilant as a potential treatment for people with Cushing’s syndrome due to either an adrenal tumor or enlargement of the adrenal gland, the company announced. “GRADIENT is the first systematic…
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Ketoconazole May Be Better Choice for Cushing’s Syndrome Patients When Surgery Is Not Available
Note: This story was updated Aug. 6, 2020, to note that ketoconazole is approved to treat Cushing’s in Europe and is used off-label for the same indication in the U.S. In cases where surgery is temporarily unavailable for Cushing’s syndrome patients due to the COVID-19 pandemic, a…
Isturisa (osilodrostat) is now available in Germany to treat adults with endogenous Cushing’s syndrome. The announcement by Recordati Rare Diseases, which acquired rights to Isturisa from its original developer Novartis, follows the medication recently becoming available in the U.S. and in France. Isturisa…
A newly developed smart contact lens might be used to measure levels of the hormone cortisol in a person’s tears, which could be helpful in disorders such as Cushing’s disease. The new device was described in Science Advances, in the study, “Smart, soft contact lens for…
Estrogen receptor alpha — one of the two main types of protein receptors activated by the female sex hormone estrogen — likely is involved in the development of Cushing’s syndrome during pregnancy. The study with that finding, “Estrogen receptor α plays an important role…
The last patient has completed the last study visit in the withdrawal phase of the Phase 3 LOGICS clinical trial that is investigating the safety and effectiveness of Recorlev (levoketoconazole) in patients with endogenous Cushing’s syndrome. The announcement by Strongbridge Biopharma, the therapy’s developer, says that LOGICS…
The EveryLife Foundation for Rare Diseases has launched a nationwide National Burden of Rare Disease Survey to measure the full implications, economic and social, of living with rare disease in the United States. People with rare diseases know that the impacts of such conditions extend beyond just medical…
The proportion of Cushing’s syndrome patients whose disease is caused by a tumor in the adrenal glands is higher in Asia than in other continents. Now, researchers in Thailand suggest that countries in Southeast Asia also may have a higher incidence of this subtype of cases. The research, “…
Recordati’s Isturisa (osilodrostat) safely and effectively normalizes urinary levels of cortisol in people with endogenous Cushing’s syndrome other than Cushing’s disease, according to data from a Phase 2 clinical trial in Japan. Endogenous Cushing’s syndrome occurs when the body produces abnormally high levels of the…
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