News

Targeting the USP8 protein, which is frequently mutated in Cushing’s disease patients, lowered the levels of adrenocorticotropic hormone, inhibited cell proliferation, and caused cell death in a mouse cell model of the disease, a study found. As a result, USP8 may be a promising target for therapies…

Symptoms associated with the risk of heart disease or stroke are common in people with asymptomatic tumors of the adrenal glands – called adrenal incidentalomas – particularly those that produce excess cortisol, a review of studies found. Problems such as high blood pressure, impaired blood…

People with Cushing’s disease are much more likely than others to develop blood clots, including rare ones in the brain, even after a pituitary surgery normalizes their cortisol levels, a case report shows. This finding suggests that patients should be managed with prophylactic (preventive) blood thinners from diagnosis and…

Genetic variations in the glucocorticoid receptor may explain why some patients with Cushing’s syndrome lose muscle strength, a study suggests. The study, “Glucocorticoid receptor polymorphisms influence muscle strength in Cushing’s syndrome,” was published in The Journal of Clinical Endocrinology & Metabolism. Cushing’s syndrome is caused…

Doctors should suspect Cushing’s syndrome in cases of depression that do  not respond to medication or other interventions, avoiding misdiagnosis and unnecessary treatment, a case report suggests. While reducing cortisol levels often is enough to improve the depressive symptoms experienced by some Cushing’s patients — as occurred in this case…

Long-term use of topical corticosteroids to treat skin problems can trigger secondary Cushing’s syndrome in adults, with a severe impact on bone health, a case report shows. The study, “Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report,” was published in the journal…

Abnormal fat accumulation, including increased bone marrow fat and insulin resistance,  can lead to bone loss and a greater likelihood of fractures in people with Cushing’s disease, researchers report. Their study, “Beyond the…

Proper characterization of the features of double pituitary adenomas in patients with Cushing’s disease is key for an accurate diagnosis and successful surgical removal, a study highlights. The study, “Double Pituitary Adenomas in a Large Surgical Series,” was published in the journal Pituitary. Most pituitary adenomas…

Surgically removing both adrenal glands is a safe and effective way to control excessive cortisol levels in people with Cushing’s disease who fail to improve after pituitary surgery or through medication, a study suggests. Findings also showed that levels of adrenocorticotropic hormone (ACTH) and cortisol, as well as excess…

While men and women with adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome have distinct symptoms and signs, these differences do not justify divergent diagnostic or treatment approaches since both sexes have similar outcomes, a study shows. Disease recurrence and survival are comparable for both men and women with Cushing’s…