News

Cushing’s syndrome patients deemed in biological remission are rarely functionally cured, continuing to report low quality of life scores, chronic depression, and the need for specific working arrangements in the long term, a study reports. Researchers point to neurocognitive damage — mainly depression — as a major player in…

A precise form of radiation therapy, known as Gamma Knife radiosurgery, produces a low rate of adverse radiation effects and provides good tumor control when used as an upfront treatment strategy in Cushing’s disease patients, an international study suggests. The study, “Upfront Gamma Knife radiosurgery for…

High levels of inflammatory cytokines — molecules that mediate the body’s immune response — may increase the risk of metabolic and heart disease in subclinical Cushing’s syndrome patients, a retrospective study shows. The study, “Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing’s syndrome and healthy controls,”…

In Cushing’s disease (CD), depression is correlated with body image distortion and lower self-esteem, according to an Indian study. Physicians should be attentive to symptoms of mental disturbances in CD patients to provide them a better prognosis. The research, “A Study on Psychiatric Disorders, Body Image…

The Endocrine Society has selected 13 leaders in the endocrinology field as winners of its prestigious 2019 Laureate Awards. Among the recipients is James W. Findling, MD, an expert in Cushing’s disease. Each recipient will be presented with the award at ENDO 2019,…

Medical therapy using cabergoline is an option for treating patients with persistent or recurrent Cushing’s disease after transsphenoidal surgery, new research from India shows. The study, “Effect of cabergoline monotherapy in Cushing’s disease: an individual participant data meta‑analysis,” was published in the Journal of Endocrinological Investigation. Cushing’s disease is most…

Minimally invasive diagnostic methods and transnasal surgery may lead to remission in nearly all children with Cushing’s disease, while avoiding more aggressive approaches such as radiation or  removal of the adrenal glands, a study shows. The study, “A personal series of 100 children operated for Cushing’s…

OvaScience and Millendo Therapeutics will merge in an all-stock deal to push forward Millendo’s lead candidates livoletide (AZP-531) and nevanimibe (ATR-101) for the treatment of Prader-Willi syndrome and Cushing’s syndrome, respectively. An investor group that includes New Enterprise Associates, Frazier Healthcare Partners, Roche…

Recorlev (levoketoconazole) safely and successfully reduces the levels of cortisol in patients with endogenous Cushing’s syndrome, according to top-line results of a Phase 3 clinical trial. Cushing’s syndrome occurs due to abnormally high levels of cortisol, mainly caused by prolonged exposure to cortisol-like steroid medications and less commonly by…

A test using betamethasone — a corticosteroid that causes the pituitary gland to stop producing ACTH – can accurately predict short- and long-term remission in Cushing’s disease patients who have had pituitary surgery, a retrospective study reports. The research, “An early post-operative ACTH suppression test can safely predict short- and long-term…